摘要
目的：探讨强直性脊柱炎（ＡＳ）患者发生髋关节病变的可能危险因素。方法：对６６例有髋关节破坏的ＡＳ患者（Ａ组），和４８例有髋痛但Ｘ线正常患者（Ｂ组）进行回顾性分析，并与３４例无髋关节病变的ＡＳ患者（Ｃ组）做对照。结果：Ａ组及Ｂ组的发病年龄均早于Ｃ组（Ｐ＜００５）。以外周关节起病者，在三组分别为６９７％，５９３％和２０６％（Ｐ＜００１）；发病至出现髋痛的间隔时间在Ａ组短于Ｂ组（Ｐ＜００１），以髋关节起病者则在Ａ组多于Ｂ组（Ｐ＜００１）；ＥＳＲ，ＣＲＰ和ＩｇＧ水平在Ａ组均高于Ｂ组（Ｐ＜００１）。结论：发病年龄早，以外周关节起病者易发生髋关节受累；早期或发病即有髋关节受累。
Objective:To analyze the possible risk factors for ankylosing spondylitis (AS) patients developing hip joint disease.Methods:Sixty six patients with X ray manifestations of hip joint disease(group A),and 48 patients with hip pain and without X ray changes (group B) were analyzed,and compared with 34 patients without hip joint involvement(group C).Results:The mean age at the time of disease onset was 19 0 years±6 3 years old in group A,20 1 years±6 8 years in group B and 24 3 years±9 8 years ( P <0 05) in group C.Involvement of peripheral joints as the first signs occurred in 69 7%,59 3% and 20 6% ( P <0 01) of patients in group A,group B and group C respectively.The interval time between disease onset and the involvement of hip joint was shorter in group A than that in group B ( P <0 01) and there were more patients who had hip pain at the disease onset in group A than in group B (48 5% vs 22 9%, P <0 01),Laboratory findings showed that ESR,CRP and IgG levels were higher in group A than those in group B ( P <0 01).Conclusion:Patients with younger age at onset or with peripheral joint involvement as initial manifestations are more likely to develop hip joint disease,and patients with involvement of hip joint at early disease course,with higher levels of ESR,CRP and IgG,are predisposed to having destructive hip joint disease.
出处
《中华风湿病学杂志》
CAS
CSCD
1998年第4期192-195,共4页
Chinese Journal of Rheumatology
