摘要
目的分析心脏粘液瘤复发原因,探讨其新的临床分型方案。方法回顾分析我院2005年10月和2004年12月分别收治的2例心脏粘液瘤复发患者的临床资料,均为女性,年龄分别为33岁和42岁。使用维普全文数据库系统,检索关键词为心脏粘液瘤的文献,复习国内1994年1月至2008年12月14年间所发表的有关粘液瘤患者外科治疗的大组报告(随访时间大于4年)和复发个案报道。结果复习大组报道的粘液瘤1969例,其中复发60例,复发率为3.0%;粘液瘤复发个案报道15例。数据分析结果:单蒂复发率为3.0%(3/99),多蒂为35.7%(5/14);多腔室分布复发率为41.7%(5/12)和33.3%(3/9);复发间隔时间平均4.1年;多次复发9例(12.0%),最多4次;复发时恶变1例;再手术率64.0%(32/50);有家族及遗传倾向的6例(8.0%)。我们将心脏粘液瘤分为典型和非典型两类。典型粘液瘤指肿瘤起源于房间隔卵圆窝附近、单蒂、局限于左心房、无基因异常证据的粘液瘤;非典型粘液瘤包括家族性、多点多腔室分布、左心房非常规位置起源、有明确基因异常、病理提示有恶性倾向的粘液瘤。结论多点、多腔室分布和左心房非常规位置起源的非典型心脏粘液瘤更易复发,术后需严密随访。
Objective To analyze the causes of cardiac myxoma recurrence and discuss its clinical classification. Methods We reviewed the data of two female patients, aged thirty three and forty two, with recurrent cardiac myxoma, who were admitted into our hospital separately in December 2004 and October 2005. We searched articles with ＂cardiac myxoma＂ as the key words at www.cqvip.com, and reviewed literature of big case groups having undergone surgical operations, case reports of recurrence and literature with a follow-up time longer than 4 years between January 1994 and December 2008. Results We reviewed a total of 1 969 cases of cardiac myxoma, in which there were 60 recurrent cases with a recurrence rate of 3.0%, and there were 15 recurrence case reports. Data analysis showed that single -pedicle recurrence rate was 3.0% （3/99） and multiple -pedicle recurrence rate was 35.7% （5/14）; In two reports on cardiac myxoma distributed in multiple chambers, the recurrence rate was 41.7% （5/12） and 33.3% （3/9） respectively; Average interval of recurrence was 4.1 years; Repeated recurrence happened to 9 cases （12.0%） with the most repetition times of 4 in one case; Malignancy on recurrence was found in one case; Reoperation rate was 64.0% （32/50）; Six cases （8.0%） were familial myxoma. Accordingly, we advocate a clinical classification of ＂typical＂ and ＂atypical＂ cardiac myxoma. The typical myxoma refers to the tumors located at left atrium with single pedicle, rooted at or around fossa ovalis, and without abnormal DNA, while the atypical myxoma are familial tumors and tumors stemming from multiple points or multiple chambers, rooted in abnormal position of the left atrium, arising from clear gene mutation, or with malignant tendency. Conclusion Myxomas with multiple pedicles, distributed in more than one chamber, and rooted in abnormal position of the left atrium have a much higher recurrence rate. Close follow-up is needed for above-mentioned patients to achieve an optimal treatment results.
出处
《中国胸心血管外科临床杂志》
CAS
2010年第1期13-17,共5页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
心脏粘液瘤
复发
基因异常
Cardiac myxoma
Recurrence
Abnormal DNA
