摘要
目的建立了盐酸特拉唑嗪胶囊剂溶出度的测定方法。方法采用转蓝法,500ml盐酸溶液(9ml→1000ml)为溶出介质,转速:100r/min,45min取样,245nm波长处分光光度法检测。结果盐酸特拉唑嗪的溶出度含量在2.0-6.0μg/ml(r=0.9995,n=5)范围内呈良好的线性关系,平均回收率100.9%,RSD为1.4%。结论采用紫外分光光度法测定盐酸特拉唑嗪胶囊溶出度操作简便,结果准确,能够用于盐酸特拉唑嗪胶囊剂的质量控制。
Objective To establish a ultraviolet spectrophotometry method for determining the dissolution in terazosin hydrochloride capsule. Methods The stirring basket method was used to detect the dissolution rate for terazosin hydrochloride capsule at 245 nm with chlorhydric acid solution（9 ml--1000 ml）500 ml as the dissolution mediator at the rate of 100 r/ min. Results The calibrated linear curve of terazosin hydrochloride was in the range of 2.0 - 6.0μg/ml （ r = 0. 999 5, n = 5 ）. The recovery rate was 100.9 % with RSD of 1.4%. Conclusion The method is proved to be accurate and reliable for the quality control of terazosin hydrochloride capsule.
出处
《山西医科大学学报》
CAS
2010年第3期227-230,共4页
Journal of Shanxi Medical University
关键词
盐酸特拉唑嗪
胶囊剂
溶出度
质量控制
terazosin hydrochloride
capsule
dissolution
quality control
