摘要
肝癌复发和转移是多步骤、多因素参与的复杂过程。在临床治疗方面，根治性手术切除或肝移植术后70％以上的肝癌患者可发生肿瘤复发或远处转移，90％以上导致患者死亡的因素与肿瘤转移和复发有关。由此可见，肝癌复发和转移是影响患者获得长期生存的重要因素。虽然目前还未完全揭示肝癌复发和转移的机制，但相关临床和基础的研究结果为我们提供了一些新的思路。
Cancer metastasis is considered as a complex process involving a series of sequential steps and a variety of molecular signal transduction pathways. Tumor recurrence and metastasis are major obstacles for long-term survival of liver cancer patients. Although the prognosis after recurrence and metastasis is dismal, the advancement of molecular researches of metastasis of liver cancer seems promising. In studies of origins of metastasis of liver cancer, the primary cancer cell and corresponding metastatic liver cancer cells share similar gene signature, which indicates that genes favoring metastasis progression are initiated in the primary tumors. The metastasis of liver cancer may be an early event in hepatic carcinogenesis and progression. Some molecular signatures have been developed to classify the metastatic potential of liver cancer. Furthermore, a variety of studies demonstrate that the tumor microenvironment instead of tumor cells plays a more important role in liver cancer metastasis. The pre-metastatic niche composed of non-tumoral cells may promote the cancer cell sedimentation and progression. The theory of cancer stem cell speculates that cancer stem cells were the real source of recurrent or metastatic tumors. Cancer stem cells will be one of the main targets of liver cancer treatment. The prevention and treatment of liver cancer recurrence or metastasis are quite difficult because liver cancer is resistant to traditional chemotherapy. Targeting the molecules involved in the metastasis of liver cancer would be promising to cure those diseases.
出处
《中华消化外科杂志》
CAS
CSCD
2010年第1期10-11,共2页
Chinese Journal of Digestive Surgery
基金
基金项目：十一五国家科技支撑计划重大项目（2006BA102A04）
关键词
肝肿瘤
复发
转移
Liver neoplasms
Recurrence
Metastasis
