摘要
目的：研究骁悉（ＭＭＦ）对移植肾的免疫抑制作用，观察其副作用与毒性反应。方法：选择（ａ）３５例免疫抑制药物初次服用者；（ｂ）１８例药物性肝中毒者；（ｃ）８例常规免疫抑制治疗方案下出现急性排斥反应（ＡＲ）、经治疗逆转后使用ＭＭＦ者；（ｄ）９例术后远期出现慢性排斥（ＣＲ）接受ＭＭＦ治疗者。结果：（ａ）５．７１％出现ＡＲ；（ｂ）肝功能逐步恢复，无ＡＲ；（ｃ）未发生二次急性排斥反应；（ｄ）蛋白尿减轻，肾功能得到控制者占８８．８９％。所有ＭＭＦ使用者４例血白细胞减少，６例腹泻，２例腹痛。结论：ＭＭＦ的免疫抑制作用确切，可显著降低ＡＲ发生率，对ＣＲ亦有预防与治疗作用。
OBJECTIVE To study the immunoinhibitory effect of mycophenolate mofetil(MMF)and to observe MMF associated side effects in renal graft recipients. METHODOLOGY This study included 70 cases of renal transplantation patients who used MMF in stead of Azathioprine(Aza)in their anti rejection regimes.Among these 70 patients,there were 35 cases who used MMF in their initial regime of anti rejection,18 out of 70 patients with drug associated liver damage,8 switched to MMF for acute rejection(AR)after the traditional regime.Most of the patients used MMF at a dosage of 0 75g twice a day except a few patients at 1g twice a day. RESULTS The rate of acute rejection in this group of patients was 5 71%.An improvement of liver function was observed in patients with drug associated liver damage.No AR was observed in these patients.In patients with chronic rejection(CR),the deterioration of renal function was controlled in 88 89% of patients and the severity of urinary protein excretion was improved.The remained 11 11% of CR patients did not respond to MMF treatment and proceed to end stage renal failure.Among the patients taking MMF,there were 4 complicated with leukocytopenia,6 with diarrhoea and 2 with abdominal pain. CONCLUSION MMF is effective in preventing acute and chronic renal graft rejection.It is also recommended in renal transplant patients with liver lesion.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1998年第6期520-522,共3页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
肾移植
骁悉
免疫抑制剂
副作用
毒性反应
kidney transplantation mycophenolate mofetil immunoinhibitory
