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BDNF及其受体TrkB在颞叶癫组织中的表达及意义 被引量：1

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摘要 目的探讨脑源性神经营养因子(BDNF)和其特异性受体TrkB的表达与颞叶癫(TLE)之间的关系。方法选取52例难治性TLE患者术中切除的颞叶、海马及癫灶组织,用免疫组化SP法对其组织中BDNF及TrkB含量进行检测,并与12例对照组进行比较研究。结果(1)在难治性TLE患者中,BDNF、TrkB在颞叶、海马及癫灶组织中含量较对照组明显增加(均P<0.05)。(2)BDNF、TrkB两者的表达呈正相关(r=0.545,P<0.01)。结论难治性TLE患者的颞叶、海马及癫灶组织中BDNF及TrkB含量显著增高,且两者的表达呈正相关,提示其可能对TLE的发作、持续及终止起重要作用。
作者 高涛 王新军 牛光明
机构地区 郑州大学第二附属医院神经外科 郑州大学第五附属医院神经外科
出处 《中国实用神经疾病杂志》 2010年第5期40-42,共3页 Chinese Journal of Practical Nervous Diseases
关键词 难治性颞叶癫 BDNF TrkB 免疫组化
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献7

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共引文献14

同被引文献10

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中国实用神经疾病杂志
2010年 第5期

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