摘要
目的比较紫杉醇联合奈达铂与联合顺铂或卡铂治疗晚期或复发性头颈部鳞癌的疗效。方法回顾性分析河南科技大学第一附属医院2003～2009年间紫杉醇联合铂类化疗的晚期或复发性头颈部鳞癌患者105例，分为顺铂或卡铂组和奈达铂组。紫杉醇均按135mg／m^2静脉滴注3h，第1天给予；顺铂75mg／m^2静脉滴注，分第1～3天；卡铂按AUC=5静脉滴注，第2天；奈达铂按80mg／m^2静脉滴注，分1～3天。2组均每3周为1个周期，每2个周期评价疗效，对2组缓解率、不良反应进行比较。结果2组总缓解率、各种不良反应均无统计学差异，但在1a内用过铂类治疗的患者中，奈达铂组缓解率与顺铂或卡铂组比较有统计学差异（P=0．043）。结论1a内未曾用铂类化疗的患者中紫杉醇联合顺铂或卡铂、奈达铂的疗效不良反应相同，而1a内曾用过铂类的患者中奈达铂疗效较好。
Objective To compare the efficacy between paclitaxel plus Nedaplatin regimen and paclitaxel plus cisplatin or carboplatin regimen for advanced or recurred head and neck carcinoma.Methods 105 patients with advanced or recurred head and neck carcinoma were analyzed and treated with paclitaxel plus platinum analogs regimen from 2003 to 2009.All the patients were divided into Cispl'atin or carboplafin group and Nedaplatin group.All the patients were given infusion of paclitaxel(135 rog/m2) at day 1.The patients in Cisplatin or carboplatin group received infusion of cisplatin(total dose was 75 rog/m2) at Days 1-3 orcarboplafin(AUC=5) at Day 2;Nedaplatin group received infusion of nedaplatin(total dose was 80 rog/m2) at Days 1-3.One cycle was 21 days.After 2-3 cycles of treatment,the remission rate and side effects were compared.Results The differences of remission rate and side effects rate between the two groups all had no statistical significance,while the difference was statistical between the two groups in the patients given platin analogs in one year.Conclusion The efficacy and side effects of paclitaxel plus,the platin analogs forregimens are same in all patients while the efficacy of Nedaplatin plus paclitaxel regimen is better than the others.
出处
《河南职工医学院学报》
2010年第1期16-18,共3页
Journal of Henan Medical College For Staff and Workers
关键词
头颈部鳞癌
紫杉醇
疗效
squamous of head and neck carcinoma
paclitaxel
efficacy
