摘要
目的:观察不良孕产夫妇异常染色体分布类型及其与不良孕产的关系。方法:对516对不良孕产夫妇外周血及其中64例流产物进行细胞遗传学分析。结果:516对不良孕产史夫妇染色体异常28例(2.71%),均为结构畸变,其中相互易位23例,罗伯逊易位5例;染色体异态97例(9.40%)。64例流产物中发现染色体异常35例(54.7%)。结论:不良孕产夫妇染色体异常主要为染色体平衡易位的结构畸变,同时染色体异态在不良孕产史夫妇中发生率较高,亦应引起重视;细胞遗传学分析在不良孕产夫妇病因诊断中不容忽视。
Objective： To explore the types of chromosome abnormality in the couples with abnormal pregnancy and labor history in Henan.Method： Cytogenetic analyses were conducted on the peripheral blood of 516 couples with abnormal pregnancy and labor history as well as 64 products of conception collected.Results： Twenty-eight（2.71%） of structural aberration was found,23 of reciprocal translocation,5 of Robertsonian translocation.A total of 97（9.40%） of chromosome heteromorphism was detected.Thirty-five（54.7%） of chromosome abnormality was found in the products of conception collected.Conclusion： The chromosome abnormality of the couples with abnormal pregnancy and labor history is mainly the balanced reciprocal translocations.The high incidence of chromosome heteromorphism in the couples with abnormal pregnancy and labor history should be taken seriously.And the cytogenetic analysis means a lot to the etiologic diagnosis of abnormal pregnancy and labor.
出处
《中国计划生育学杂志》
北大核心
2010年第3期170-171,共2页
Chinese Journal of Family Planning
关键词
染色体畸变
染色体异态
不良孕产
Chromosomal aberrations
Chromosome heteromorphism
Abnormal pregnancy and labor
