摘要
目的:研究中、低强度的循环光照射对鼠视网膜光损伤的影响及其与时间、强度的关系。方法:25只8～10周的雌性SD鼠随机分为5组。一组作对照,另外四组置于12小时亮、12小时暗的白色氙灯循环光下照射3～28天,照射强度分别为90～115Lux(100Lux)、400～650Lux(500Lux)、800～1150Lux(1000Lux)、1400～1650Lux(1500Lux)。照射不同时间后,对视网膜行光镜、电镜检查及组织测厚。结果:除100Lux组光强度外,500Lux、1000Lux、1500Lux组的光强度均能引起鼠视网膜光损伤。视网膜光感受器细胞最早受累。光强度越高、照射时间越长,光感受器细胞的丧失越多;损伤严重者,也伴有视网膜色素上皮的损伤。结论:中、低强度的循环光所造成的鼠视网膜光损伤,其损伤程度与光照强度和照射时间有关。是光损伤防护中值得注意的环节。眼科学报1998;14:215～219。
Purpose: To study the influences of moderate-and low intensity of cyclic light exposure on the light damage of rat retina and its relationship with light intensity and exposure duration.
Methods: Twenty five 8-10 weeks old of female Sprague-Dawley rats were divided into 5 groups randomly. One group were as controls reared in dark-room,others were exposured to 12 hour light; 12 hour dark cyclic white xenon light from 3 to 28 days. The light intensities were 90- 115Lx(100Lux),400-650Lux(500Lux),800-1 150Lux(1000Lux),1 400 - 1 650Lux( 1 500Lux)separately. After various duration of exposure, the retina were evaluated with light microscopy, electron microscopy and morphometric study. Results:Except for the intensity of 100Lux group, all of the other exposure intensities can induce the light damage of rat retina. The photoreceptor cells were affected most early. The higher of light intensity and the longer of exposure duration, the severer of the photoreceptor cell loss. In the severely damaged eye,RPE were also damaged.
Conclusions : For the light damage of rat retina which is induced by moderate-or low intensity of cyclic light, the damage degree was both affected by light intensity and exposure duration. Eye Science 1998 ; 14 :215 - 219.
出处
《眼科学报》
1998年第4期215-219,共5页
Eye Science
