摘要
目的探讨相对健康的中老年人血清瘦素与脂联素水平与心脑血管疾病危险因素的相关性。方法从“广州生物库队列研究”中收集1515名相对健康的50岁及以上的中老年人个人资料及病史、体格检查并测定血清空腹血糖、血脂、瘦素和脂联素的水平。结果（1）广州市1515名的血清瘦素水平（^-x±s）男女性分别为（3．90±2．36）ng／ml和（12．17±2．01）ng／ml；脂联素水平男女性分别为（5．33±2．78）mg／L和（7．18±2．58）mg／L。（2）男女性血清瘦素和脂联素水平均随年龄增长而升高；在捌整BMI后，男性瘦素水平仍随年龄增长而显著升高（趋势检验P〈0．001），而女性其脂联素水平也随年龄增长而显著升高（趋势检验P〈0．05）。（3）在调整年龄后，男女性血清瘦素和脂联素水平均与吸烟状态无明显相关（P=0．09—0．76）。（4）血清瘦素水平，男女性均随腰围、BMI、SBP、LDL—C和TG增加而显著升高（P=0．04，〈0．001），同时还随男性的DBP和空腹缸糖升高及HDL—C降低而硅著升高（P=0．03～0．02）。（5）血清脂联素水平男女性均随腹同以及TG升高而下降（P=0．003，〈0．001），而男性血清脂联素水平还随BMI与空腹血糖升高及HDL－C水平下降而下降（P=0．05，〈0．001），女性则随SBP和TC上升而下降（P＝0．05～0．006）。结论广州市相对健康的中老年人血清瘦素和脂联素水平男性比女性低；男性瘦素水平和女性脂联素水平同年龄增加呈显著相关。血清瘦素升高和脂联素下降与传统心腑血管危险因素上升有关。
Objective To study the serum leptin and adiponectin levels among relatively healthy older people and their association with traditional cardiovascular risk factors. Methods Personal medical history and blood sample were collected from 1515 older people of Guangzhou. Fasting serum glucose, lipids, leptin and adiponectin were measured. Results （1）In relatively healthy older adults aged 50 or above, from Guangzhou, the following data were seen： serum leptin levels （^-x± s ） in men and women were （3.90 ± 2.36） ng/ml and （ 12.17± 2.01 ）ng/ml respectively; serum adiponectin levels in men and women were （5.33 ± 2.78） mg/L and （7.18 ± 2.58） mg/L respectively. （2）Serum leptin and adiponectin level increased with age. After adjusting for body mass index, the trend for serum leptin level in men （P〈0.001） and adiponectin level in women （P〈0.05） were significantly associated with age. （3）No association was found between cigarette smoking and levels of leptin or adiponectin in both men and women after adjusting for age （P from 0.09 to 0.76）. （4）In both men and women, serum leptin and adiponectin levels were positively associated with waist circumference/body mass index, systolic blood pressure, low-density lipoprotein cholesterol and triglyceride （P from 0.04 to 〈0.001）. In men, leptin was also significantly associated with the increase of diastolic blood pressure and glucose but decreased with high-density lipoprotein cholesterol （P from 0.03 to 0.02）. （5） Decreased adiponectin level was associated with increased waist circumference and triglyceride in both men and women （P from 0.003 to 〈0.001 ） and with the increased body mass index, fasting plasma glucose as well as with decreased high-density lipoprotein cholesterol in men （P from 0.05 to 〈0.001） but with increased systolic blood pressure and total cholesterol in women （P from 0.05 to 0.006）. Conclusion In Guangzhou city, among relatively healthy older adults aged 50 or above, their serum leptin and adiponectin levels were lower in men than in women. Serum leptin level in men and adiponectin level in women were significantly associated with the increase of age. Increased leptin and decreased adiponectin levels were associated with increased traditional cardiovascular risk factors.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2010年第2期121-125,共5页
Chinese Journal of Epidemiology
基金
基金项目：同家自然科学基金（30518001）
香港研究资助局课题（HKU720/05）
关键词
瘦素
脂联素
中老年人
危险冈素
Leptin
Adiponectin
Older people
Risk factors
