摘要
用1,1,1-三羟甲基乙烷及2,2-二羟甲基丙酸为原料合成了树型分子R(CH2OH)6;然后以此树形分子引发ε-己内酯开环聚合,得到了六臂星形聚己内酯(Star PCL);再通过DCC使叶酸与星形聚己内酯各臂链端的羟基官反应,得到了链端接枝叶酸的星形聚己内酯(StarPCL-FA)。1H-NMR和FT-IR确证了产物的结构。结果表明,成功地制备了六臂星形聚己内酯-叶酸材料,它们有望成为一类新型的肿瘤靶向药物载体材料。
Star-shaped poly（ε-caprolactone）s（Star PCLs） with six arms were successfully synthesized via ring-opening polymerization of ε-caprolactone initiated by a dendrimer which was synthesized by TME and 2,2-bishydroxymethylepropanoic acid.Then by conjugating the end hydroxyl groups of Star PCLs with the carboxyl groups of folic acid,star-shaped poly（ε-caprolactone）s with folates（Star PCL-FAs） were obtained.Characterizations of these materials by 1H-NMR,FT-IR were carried out.The results showed that the arm number of the Star PCLs was in accordance with the hydroxyl group number of the initiator and the conjugation of folic acid was successful.These polymers are expected to be used as drug carriers for targeted drug delivery.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2010年第2期222-224,共3页
Journal of Functional Materials
基金
国家自然科学基金资助项目(50873065)
国际科技合作重点资助项目(2006DFA53470)
关键词
星形聚合物
聚己内酯
叶酸
药物载体
star-shaped polymer
PCL
folic acid
drug carrier materials
