急性脑梗死患者同型半胱氨酸和超敏C反应蛋白监测的临床意义被引量：19

Clinical significance of homocystine and high-sensitivity C-reactive protein levels in patients with acute cerebral infarction

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摘要目的探讨急性脑梗死患者同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)的变化及其临床意义。方法经CT或MRI确诊的263例急性脑梗死患者为病例组,107例健康查体者作为对照组,采用免疫透射比浊法和ELISA法分别测定血清hs-CRP和血浆Hcy水平。结果急性脑梗死患者血Hcy和hs-CRP水平均明显高于对照组(P<0.01);Hcy与hs-CRP水平依照LACI、POCI、PACI、TACI亚型排序逐渐增高(P<0.05,P<0.01),与疾病的严重程度呈现明显的正相关(r=0.43和r=0.52)。结论急性脑梗死患者Hcy和hs-CRP明显升高,并且与脑梗死的严重程度呈正相关,可作为预测急性脑梗死发生发展的敏感指标。 Objective To investigate the clinical significance of homocystine （Hcy） and highsensitivity C-reactive protein （hs-CRP） levels in the patients with acute cerebral infarction （ACI）. Methods The levels of Hcy and hs-CRP in 263 patients with ACI diagnosed by CT and MRI were measured using ELISA and immunoturbidimetry methods, respectively, which were compared to those in 107 healthy subjects. Results The levels of Hcy and hs-CRP in the patients with ACI were significantly higher than those in healthy subjects （P〈0. 01）. The levels of Hcy and hs-CRP were significantly increased in an order of LACI 〈 POCI 〈 PACI 〈 TACI （P〈 0.05 or P〈 0.01 ）. In addition, the levels of Hcy and Hs-CRP were positively correlated to the extent of cerebral infarction （r;0.43 and r=0. 52）. Conclusion The levels of Hcy and hs-CRP are markedly increased in the patients with ACI, which are positively correlated to the severity of ACI and may be taken as the sensitive biochemical markers for predicting its development.

作者李艳志胡定波任利群张正生

机构地区东南大学附属中大医院老年医学科宝应县人民医院心脏病科东南大学附属中大医院神经内科

出处《江苏医药》 CAS CSCD 北大核心 2010年第3期278-280,共3页 Jiangsu Medical Journal

关键词急性脑梗死同型半胱氨酸超敏C-反应蛋白 Acute cerebral infarction Homocystine High-sensitive C-reactive protein

分类号 R743 [医药卫生—神经病学与精神病学]

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1Dirnaql U,Iadecola C,Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view[J]. Trends Neurosci, 1999,22 (9) :391-397.
2Faraci FM, Lentz SR. H yperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction[J]. Stroke, 2004, 35 (2): 345-347.
3Ridker PM, Cushman M, Stampfer MJ, et al. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease[J]. Circulation,1998,97(5):425-428.
4Purroy F, Montaner J, MolinaCA, etal. C-reactive protein predicts further ischemic events in transient ischemic attack patients[J]. Acta Neurol Scand, 2007,115 (1) : 60-66.
5Tan NC, Venketasubramanian N, Saw SM, et al. Hyperhomocyst (e) inernia and risk of ischemic stroke among young Asian adults[J]. Stroke,2002,33(8) : 1956-1962.
6刘国荣,李月春,张京芬,王宝军,耿尚勇.同型半胱氨酸与脑卒中及相关因素分析[J].脑与神经疾病杂志,2003,11(5):281-284. 被引量：21
7章成国,邵燕,胡学强.脑梗死患者血浆Hcy浓度与其临床亚型及疾病严重程度的关系研究[J].中国现代医学杂志,2003,13(13):22-24. 被引量：19

二级参考文献28

1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33100
2脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志,1996,29(6):381-383. 被引量：15809
3Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham study. Am J Cardiol, 1976; 38:46-51.
4The Pooling Project Research Group. Relationship of blood pressum, serum cholesterol, smoking habit, relative weight and ECG,abnormalities to incidence of major coronary events:final report of the pooling project. J Chronic Dis, 1978; 31:201-306.
5Kannel WB. The Framingham study: ITS 50 - year legacy and future promise. J Atheroscler Thromb,2000; 6(2):60--66.
6Bamford J, Sanderceck P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction.Lancet, 1991 ; 337(8756) : 1521 -- 1526.
7Ross R. The pathogenesis of atherosclerosisman update. N Engl J Med, 1986;314(8) :488--500.
8Masser PA, Taylor LM Jr, Porter JM. Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis. Ann Thorac Surg, 1994;58(4):1240-- 1246.
9Refsum H, Fiskerstrand T, Guttormsen AB, et al. Assessment of homocysteine status. J Inherit Metab Dis 1997, 20 : 286- 94.
10Hankey GJ,Eikelboom JW. Homocysteine and stroke. Curr Opin in Neurol, 2001,14 : 95- 102.