摘要
目的:通过对我院常见6种致病菌耐药性的分析,为临床合理用药提供依据。方法:采用回顾性调查方法对2006～2008年度临床送检标本分离的6种常见致病菌耐药性进行分析,药敏试验为K-B法,分析软件为Whonet5.2。结果:3年的革兰阴性杆菌检出率分别为72.5﹪、70.7﹪、78.9﹪,常见致病菌为大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌等,对青霉素类,第一、二代头孢菌素等耐药严重,对头孢含酶抑制剂及亚胺培南等药物敏感;革兰阳性球菌检出率分别为27.5﹪,29.3﹪,21.1﹪,常见致病菌为金黄色葡萄球菌和粪肠球菌(D群)等,对万古霉素敏感,对头孢菌素类抗生素的耐药性明显增加,多重耐药现象严重。结论:结合药敏结果合理选用抗菌药物,对减少耐药株的产生和蔓延起着重要作用。
Objective： To investigate the drug resistance of the pathogenic floras isolated from the clinical specimen in Taizhou People＇s Hospital from 2006 to 2008 and to provide the basis for the correct selection of antibiotics. Methods： The bacterium were identified with Bio-Merieux VITEK-32 system and tested with K-B method. The data were statistically analysed by the Whonet5.2 sofeware. Results： Of the isolated strains, the yearly rates .of Gram-negative bacteria were 72.5%, 70.7% and 78.9%, respectively. Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebesiella pneumoniae were found commonly. Staptococcus aurcus and Enterococcus faecalis were found commonly. The bacteria were resistant severely to penicillins and the first and second generations of cephalosporins, but very sensitive to imipenem and those containing enzyme inhibitors（cofoperzone/sulbactam and pipercillin/ tazobactam） and imipenem. The yearly rates of Gram-positive bacteria were 27.5%, 29.3% and 21. 1% respectively. Staphylococcus aureus and were found commonly. The common Gram-positive bacteria had stronger drug resistance to cephalosporins and showed severe multi-drug resistant. But they were very sensitive to vancomycin. Conclusion： Antimicrobial therapy shoud be initiated under the guidance of anti-microbial sensitive test, which is very helpful in decreasing the bacterial drug resistance.
出处
《药学与临床研究》
2010年第1期75-78,共4页
Pharmaceutical and Clinical Research
关键词
耐药性
常见致病菌
合理用药
Drug resistance
Common pathogenic bacteria
Rational use of drugs
