摘要
目的：探讨复方酸枣口服液对小鼠睡眠的影响。方法：采用1．44g／（kg·d）、4．33g／（kg·d）、12．98g／（kg·d）剂量的复方酸枣口服液给小鼠经口灌胃30d，进行直接睡眠实验、巴比妥钠睡眠潜伏期实验、戊巴比妥钠阈下剂量催眠实验和延长戊巴比妥钠睡眠时间实验。结果：与对照组比较，中、高剂量组能显著延长戊巴比妥钠诱导的小鼠睡眠时间；高剂量组小鼠睡眠潜伏期显著缩短，差异具有统计学意义（P〈0．05）。各剂量组无直接催眠作用，对小鼠体重增长、戊巴比妥钠阈下剂量催眠均无显著影响，差异无统计学意义（P〉0．05）．结论：复方酸枣口服液能显著改善小鼠睡眠作用。
Objective To discuss the effect of compound prescription jujube oral （CPGO） to improve sleep in mouse. Methods Used 1.44mL/kg.bw, 4.33gmL/kg.bw, 12.98mL/kg.bw doses, give CPGO to mouse for 30 day, then do Sleep direct experiment, Sodium sleep latency test, Sodium pentobarbital hypnosis subliminal dose of the experimental and extend the sleep time induced by pentobarbital sodium experimental. Results Compares with the control group, CPGO could obviously extension of pentobarbital sodium-induced sleep time in mice . shorten sleep latency in mice.（P〈0.05）.Other targets are insignificant Conclusion CPGO could obviously the sleep function in mice.
出处
《中医临床研究》
2010年第5期116-117,119,共3页
Clinical Journal Of Chinese Medicine
关键词
复方酸枣口服液
睡眠
酸枣仁
远志
小鼠
Compound prescription jujube oral
Sleep
jujube
semen zizyphi spinosae
Mice
