摘要
目的:探讨孕鼠被动吸烟对幼鼠学习记忆功能的影响及其机制。方法:采用反映学习记忆功能的水迷宫法测试幼鼠学习能力的改变,放射免疫测定法(IRMA)测定幼鼠小脑皮质神经生长因子的含量变化。结果:孕期被动吸烟使幼鼠学习记忆能力下降,小脑皮质神经生长因子(NGF)含量明显降低。结论:孕期被动吸烟降低幼鼠学习记忆功能可能与小脑皮质神经生长因子的合成及分泌减少有关。
Objective：To investigate the effect and mechanism of passive smoking of pregnant rats on learning and memory of neonatal rats. Methods：Morris water maze which reflects learning and memory ability was used to test neurobehavioral changes in neonatal rats,and IRMA method was used to test nerve growth factor （NGF） content in cerebellar cortex of neonatal rats. Results： Passive smoking during pregnancy decreased the learning and memory ability in neonatal rats,meanwhile content of nerve growth factor in cerebellar cortex was significantly low. Conclusion：Reduced learning and memory ability in neonatal rats offspring by passive smoking of female rats during pregnancy correlates with reduced synthesis and secretion of nerve growth factor in cerebellar cortex.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第2期188-190,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
被动吸烟
学习记忆
神经生长因子
cigarette smoking
learning and memory
nerve growth factor
