摘要
目的研究血清乳酸脱氢酶(LDH)及其同工酶,M,H亚单位值在复治多发性骨髓瘤(MM)中的临床意义。方法收集复治多发性骨髓瘤患者141例随访资料,分析LDH及其同工酶、亚单位与DS分期、ISS分期、肌酐、骨髓浆细胞数,免疫球蛋白,β2微球蛋白等的关系。结果血清总LDH与DS分期、ISS分期均未见显著联系。LDH1百分比与ISS分期呈显著负相关(P<0.01),LDH4百分比与ISS分期呈显著正相关(P<0.05)。骨髓瘤肾病肾功能不全患者LDH值及LDH4绝对值,H亚单位值与肌酐呈显著正相关(P<0.05)。LDH5百分比及绝对值与骨髓浆细胞数呈显著负相关(P<0.01,P<0.05)。结论对于复治复发性骨髓瘤患者,血清LDH同工酶与ISS分期及肾功损害的程度密切相关,LDH同工酶测定比总LDH活性更具有临床价值。
Objective To investigate the clinical significance of serum lactate dehydrogenase （LDH）and its isoenzymes,M or H subunits in the retreated patients with multiple myeloma（MM）. Methods 141 medical records of retreated patients with multiple myeloma were collected,and the relationship of LDH and its isoenzymes,subunits with DS staging system,ISS staging system,creatinine,bone marrow plasma cell percentage,immunoglobulin and microglobin was analyzed. Results Serum total LDH activity was not significantly related to DS staging system and ISS staging system. LDH1 percentages was negatively correlated with ISS staging system（P 〈 0.01）,and LDH4 percentages positively associated with ISS staging system （P 〈 0.05）. LDH activity,absolute value of LDH1,LDH2,LDH3,LDH4,and H subunits were positively linked to serum creatinine in myeloma kidney disease patients with renal inadequacy （P 〈 0.05）. Both percentage and absolute value of LDH5 were negatively correlated with bone marrow plasma cell percentage （ P 〈 0.01 and P 〈 0.05 respectively）. ConclusionThe detection of serum LDH isoenzyme is more valuable than total LDH activity in retreated patients with multiple myeloma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2010年第1期31-33,36,共4页
Journal of China Medical University
基金
辽宁省科技攻关计划项目(2004225004-11)
关键词
乳酸脱氢酶
同工酶
多发性骨髓瘤
lactate dehydrogenase
isoenzymes
multiple myeloma
