摘要
骨桥蛋白(osteopontin,OPN)是一种分泌型糖基化磷蛋白,广泛存在于各种组织和体液中,具有多种生物学活性,整合素αvβ3是其主要受体。OPN主要参与细胞的增殖、分化、迁移及黏附。目前国内外对OPN的研究主要集中在骨吸收、血管生成、动脉粥样硬化、消化系统、泌尿系统、创面愈合、皮肤纤维化、肝纤维化、肾纤维化等方面,而在肺纤维化方面的研究报道较少,现将OPN与肺纤维化的关系作一综述。
Osteopontin （OPN） is a secreted O-glycosylated phosphoprotein that exists in a variety of tissues and body fluids, with a variety of biological activity. Integrin avβ3 is the main receptor. OPN mainly involves in cell proliferation, differentiation, migration and adhesion. The study of OPN at home and abroad mainly focuses on the bone resorption, angiogenesis, ath- erosclerosis, digestive system, urinary system, wound healing,skin fibrosis, liver fibrosis, kidney fibrosis, etc. But reports about OPN in pulmonary fibrosis are much less, now the relationships between OPN and pulmonary fibrosis are reviewed.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2010年第2期151-155,共5页
Chinese Pharmacological Bulletin
基金
江苏省中医药管理局资助项目(NoH807088)
香港保健协会研究资助项目(No20070909-1
HK)
关键词
骨桥蛋白
肺纤维化
细胞外基质
成纤维细胞
肺泡上皮细胞
上皮间充质转变
信号通路
osteopontin
pulmonary fibrosis
extracellular matrix
fibroblast
alveolar epithelial cell
epithelial-mesenchymaltransition
signal transduction
