摘要
目的探讨影响重型溶血尿毒综合征(HUS)的预后因素,并评价治疗方法。方法分析10例重型HUS患儿临床资料,采用血浆置换加连续血液净化等综合治疗措施。结果本组病例急性期均存活,溶血控制,肾及其他各脏器功能大多恢复正常。随访时间3个月至10年,血压、尿素氮(BUN)、肌酐(CRE)恢复正常8例,尿常规正常7例,尿常规轻度异常3例;反复发生溶血并急性肾功能衰竭3例,经积极治疗溶血控制,BUN、CRE均恢复正常;尿液检查正常1例,轻度蛋白尿、血尿1例,发展为慢性肾功能不全1例。结论影响预后的主要因素为急性期病情轻重及是否早期采用以血浆置换加血液净化为主等综合治疗措施。
Objective To investigate factors affecting prognosis and evaluate treatments about severe hemolytic uremic syndrome（HUS）.Methods Clinical analysis of 10 cases of children with severe HUS,Comprehensive measures including sequential plasma exchange（PE）and continuous blood parification（CBP）were adopted.Results They were all survived patients at acute phase,and hemolysis control,the function of kidney and other organ recovered.Follow-up period was 3 months to 10 years,and 8 cases had normal blood pressure,blood urea nitrogen,creatine,7cases had normal urine analysis,and 3 cases had mild abnormal urine.Of 3 cases relapse repeatedly,One case returned to normal,one case had mild proteinuria and one case developed chronic renal insufficiency.Conclusion The main factors affecting prognosis of HUS are disease＇s severity,prompt and appropriate therapy including sequential PE and CBP.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第3期296-297,共2页
Chongqing medicine
关键词
溶血尿毒综合征
治疗
预后
儿童
hemolytic uremic syndrome
prognosis
trealment
child
