棕榈酸对胰岛β细胞激素敏感性脂肪酶的影响
摘要
长期的高脂会造成胰岛β细胞胰岛素分泌障碍和三酰甘油（TG）的堆积．而过度堆积的TG是脂毒性的重要表现。激素敏感性脂肪酶（HSL）是催化TG水解的限速酶，在胰岛β细胞内表达和活化，并可能与胰岛素分泌及β细胞TG堆积有关。但是高脂对HSL的影响并不十分清楚。因此，本实验以不同浓度棕榈酸培养胰岛β细胞，观察其HSL的变化。
出处
《中华胰腺病杂志》
CAS
2010年第1期57-59,共3页
Chinese Journal of Pancreatology
基金
基金项目：湖北省自然基金（2003AA143）
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