摘要
研究了有机相中脂肪酶催化的炔丙醇酮乙酸酯的立体选择性醇解反应,考察了碱的种类、酰基受体和溶剂等对反应的影响.结果表明,以四氢呋喃为溶剂,CH3OH为酰基受体,Lipase PLG脂肪酶为催化剂,Na2CO3为碱性添加剂,高底物浓度下40oC反应96h后,底物转化率和产物ee值分别达到49.5%和99.5%.碱的添加极大地提高了反应速度.
Kinetic resolution of(RS)-4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone(HMPC)acetate was carried out successfully by lipase-catalyzed alcoholysis in organic media.Using tetrahydrofuran as the solvent,methanol as the acyl acceptor,and lipase PLG as the catalyst,the conversion of substrate and the ee value of product were 49.5%and 99.5%,respectively,after 96 h reaction at 40℃and high substrate concentration.It is noteworthy that basic additives can significantly promote the reaction.
作者
程咏梅
吴坚平
徐刚
杨立荣
CHENG Yongmei;WU Jianping;XU Gang;YANG Lirong(Department of Chemical and Biochemical Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China)
出处
《催化学报》
SCIE
CAS
CSCD
北大核心
2010年第2期225-228,共4页
基金
国家自然科学基金(20606030)
国家自然科学基金重点项目(20936002)
国家高技术研究发展计划(863计划
2006AA02Z238)
国家重点基础研究发展计划(973计划
2009CB724706)
关键词
脂肪酶
炔丙醇酮
炔丙醇酮乙酸酯
醇解
碱性添加剂
lipase
(RS)-4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone
(RS)-4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone acetate
alcoholysis
basic additive
