摘要
为了克服壳聚糖只能溶于酸性水溶液的局限，对壳聚糖进行了化学修饰，通过引入磷酸基官能团，合成了可溶于中性水的壳聚糖衍生物—磷酸化壳聚糖。以磷酸化壳聚糖和羧甲基壳聚糖为基材，用聚电解质复合法制备了印楝素／羧甲基壳聚糖／磷酸化壳聚糖纳米粒子水分散制剂。测试结果表明，纳米粒子的平均粒径为200—300nm，纳米粒子对印楝素的负载率最大可达43．5％。
In order to overcome the disadvantage （ dissolved only in acid water solution） of chitosan, chitosan was modified by chemical method. A water-soluble chitosan derivative phosphorylation chitosan （ PCS ） was synthesized by introducing phosphonic group into chitosan. According to the static electric interaction between positive polyelectmlyte and negative polyeleetrolyte, azadirach2 tin/carboxymethyl chitosan （CMC）/PCS dispersible formulation was prepared by using PCS and CMC as basic materials. The experimental results show that the particle size of azadirachtin/CMC/PCS nanoparticles is between 200 nm and 300 nm. The encapsulation efficiency of the nanoparticles to azadirachtin is up to 43.5%.
出处
《江西农业学报》
CAS
2010年第1期69-73,共5页
Acta Agriculturae Jiangxi
基金
国家自然科学基金项目(30771419
30971915)
关键词
壳聚糖
羧甲基壳聚糖
磷酸化壳聚糖
纳米粒子
印楝素
制备
Chitosan
Carboxymethyl chitosan
Phosphonic ehitosan
Nanoparticle
Azadirachtin
Preparation
