摘要
目的:了解重症监护治疗病房(ICU)分离菌对抗菌药物的耐药状况。方法:取2006年11月至2009年1月ICU患者标本做细菌培养,检出病原菌,用K-B纸片扩散法测定药敏,以表型确认法检测超广谱β内酰胺酶菌株。结果:共收集致病菌33株,其中革兰阴性杆菌29株(87.9%),革兰阳性球菌4株(12.1%)。以假单胞菌、大肠埃希菌为多。头孢哌酮/舒巴坦对革兰阴性杆菌抗菌作用最强,而万古霉素对革兰阳性球菌抗菌作用最强。结论:ICU患者感染以革兰阴性杆菌为主。头孢哌酮/舒巴坦作用最强。加强病原菌及药敏监测,以指导临床合理使用抗菌药物。
Objective： To study the antimicrobial resistance of clinical isolates from Intensive Care Unit （ICU）. Methods：The specimens of the patients who were in Bengbu Second People＇s Hospital from Nov. 2006 to Jun. 2009 were cultured to detect the pathogens. K-B agar diffusion method was used to judge drug sensitivity. Phenotypic confirmatory test was used to detect ESBLs. Results：A total of 33 clinical isolates,including 29 strains （87.9%）of Gram-positive bacilli and 4 strains （12.1%）of Gram-negative bacilli,were collected. Pseudomonas and E. coli was the main microorganism. The most active agent against Gram-negative organisms was Cefoperazone/sulbactam and Vancomycin was the most effective on Gram-positive cocci. Conclusions：The Gram-nagative bacilli was the major pathogen isolated from ICU patients; cefoperazone/sulbactam was the most effective. Pathogens and drug sensitivity monitoring should be enhanced to give guidance for rational use of antibiotics.
出处
《蚌埠医学院学报》
CAS
2010年第2期156-158,共3页
Journal of Bengbu Medical College
