摘要
本文研究了大蟾蜍(Bufo bufo gargarizans)一次性腹腔注射环磷酰胺,甲醛周血有核红细胞畸核试验的剂量—效应和时间—效应。结果表明,在一定范围内,畸核率与药物浓度存在着明显的线性剂量—效应关系。时间—效应实验数据显示,化学毒物注射后12h,畸核率达到高峰。畸核率与微核率比较,作者认为以畸核试验作为一个监测系统来监测环境诱变物和生态毒物比微核试验更敏感,更可靠,可望能作为环境污染物毒性测试的一个新的毒性指标,并为两栖类生态毒理学研究提供一个新的研究方法。
The dose-effects,time-effects on toad(Bufo bufo gargarizans)nuclei aberration test with a single intraperitioneal injection of Cyclophsphamide ( CP)and Formaldehyde ( FD ) were investigated. The experimental results showed that toad nuclei aberration rate existed a significant linear dose-response relationship in certain region. The results of data on time-effect showed that the nuclei aberration rate reached maximum 12 hr. after the toxic chemicals were injected.In addition,by comparison of nuclei aberration rate with micronuclei, frequency the author suggested that the nuclei aberration [test was more sentitive and more reliable screening system than micronuclei test in monitoring environmental mutagenes and ecotoxicity.Nuclei aberration test will probably become a new to-xicity index in the toxicity test of environmental pollutants, and a new research method for amphibian ecotoxicology.
出处
《农村生态环境》
CSCD
1990年第1期62-67,共6页
Rural Eco-Environment
