摘要
目的观察长春瑞滨(NVB)联合顺铂(DDP)、5-氟尿嘧啶(5-FU)(NPF方案)治疗晚期食道癌的近期疗效及毒副反应。方法经病理学确诊的晚期食道癌病人62例,随机分为两组,每组31例,实验组采用NPF方案化疗,对照组采用PF方案化疗,每3周重复一次,连用两周期评定疗效。结果实验组有效率高于对照组(64.5%vs41.9%,p<0.05)。主要毒副反应为骨髓抑制及消化道反应。结论长春瑞滨联合顺铂、5-氟尿嘧啶化疗方案治疗晚期食道癌疗效好,毒副反应能够赖受,值得进一步研究。
Objective To evaluate the short - term effect and adverse reaction of Vinorelbine plus cisplatin and fluorouracil in advanced esophageal cancer. Methods Sixty - two cases of pathologically confirmed advanced esophageal cancer were randomly divided into two groups （experimental group and control group）, with 31 in each group. The experimental group was treated with Vinorelbine combination cisplatin and fluorouracil, and control group was treated with cisplatin and fluorouracil. One cycle lasted 21 day, effect was evaluated after 2 cycles. Results The effective rates of the experimental group was higher than that of controlled group（ 64.5% vs 41.9% ,p 〈 0.05 ）. The main adverse reactions were myelosuppression and digestive tract reaction. Conclusion The combined chemotherapy of Vinorelbine plus cisplatin and fluoreuracil is effective and well tolerated for patients with advanced esophageal cancer. It is worthy of further clinical observation.
出处
《现代医院》
2010年第2期22-24,共3页
Modern Hospitals
关键词
长春瑞滨
联合化疗
晚期食道癌
Vinorelbine, Combined chemotherapy, Advanced esophageal cancer
