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糖尿病对离体大鼠缺血后适应心肌保护作用的影响 被引量：1

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摘要 目的探讨糖尿病对离体大鼠缺血后适应心肌保护作用的影响。方法诱导2型糖尿病大鼠模型，采用Langendorff离体心脏灌流法，全心停灌30min，复灌60min，制成心肌缺血模型；全心停灌30min后，给予再灌注10s、停灌10s6次循环，然后再灌注至60min，制备缺血后适应模型。测定血流动力学指标和复灌20min冠状动脉流出液中乳酸脱氢酶（LDH）、肌酸激酶（CK）的含量。实验结束分离出左心室心肌并横切成5片，并测定心肌梗死面积。结果糖尿病大鼠缺血后适应血流动力学无明显改善，心肌酶释放量未减低，心肌梗死面积未显著减少（50．1％±3．7％比45．7％±4．8％，P〉0．05）。结论缺血后适廊对糖尿病大鼠离体心脏无保护作用．
作者 于宏颖 赵昕 全南虎 郑杨
机构地区 黑龙江省大庆油田总医院心内科监护室 吉林大学第一医院心内科
出处 《中国心血管杂志》 2010年第1期59-61,共3页 Chinese Journal of Cardiovascular Medicine
关键词 糖尿病 2型 心肌再灌注损伤
分类号 R587.1 [医药卫生—内分泌]
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参考文献15

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同被引文献30

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中国心血管杂志
2010年 第1期

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