摘要
目的:比较齐拉西酮与利培酮对精神分裂症伴抑郁症状的疗效。方法:58例首发精神分裂症患者随机分成两组,分别给予齐拉西酮(齐拉西酮组)和利培酮(利培酮组)治疗8周,以阳性与阴性症状量表(PANSS)及汉密尔顿抑郁量表(HAMD)评定临床疗效;以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗后两组患者PANSS和HAMD评分均显著下降,齐拉西酮组改善抑郁疗效优于利培酮组。两组不良反应发生率差异无显著性。结论:齐拉西酮和利培酮治疗精神分裂症的精神病性症状疗效相当,齐拉西酮对精神分裂症抑郁症状疗效较好。
Objective： To compare the efficacy of ziprasidone and rispefidone in the treatment of the depressive symptom of schizophrenia. Method：58 patients with flint-onset schizophrenia were randomly assigned into two groups. One group was treated with ziprasidone and the other group with fispefidone for 8 weeks. Efficacy and side effects were assessed using positive and negative syndrome scale （PANSS） ,the Hamilton depressive scale（HAMD） and the treatment emergent symptom scale （TESS）. Results：The two groups showed significant decreases in PANSS and HAMD scores after the treatment, but ziprasidone was better than risperidone in the treatment of depression. There were no significant differences in side effects between the two groups. Condusion： Ziprasidone is as effective as risperidone in the treatment of the schizophrenia, and better than risperidone in treatment of depressive symptoms.
出处
《临床精神医学杂志》
2010年第1期44-45,共2页
Journal of Clinical Psychiatry
关键词
精神分裂症
抑郁症状
齐拉西酮
利培酮
schizophrenia
the depressive symptom
ziprasidone
risperidone
