摘要
目的:比较度洛西汀与文拉法辛治疗广泛性焦虑的疗效及不良反应。方法:对90例广泛性焦虑症住院患者,随机分为两组,度洛西汀组和文拉法辛组各45例,治疗8周,采用汉密尔顿焦虑量表(HAMA)和临床疗效总评量表病情严重程度(CGI-SI)评定临床疗效,用治疗中出现的症状量表(TESS)评定药物不良反应。结果:经过8周治疗,度洛西汀组和文拉法辛组有效率分别为84.44%和82.22%,两组疗效差异无统计学意义(P>0.05),两组不良反应发生率差异无统计学意义(P>0.05)。结论:度洛西汀和文拉法辛对广泛性焦虑症的疗效相当,不良反应较小,值得临床推广。
Objective： To investigate the efficacy and side effect of dutoxetine in the treatment of generalized anxiety disorder （GAD） compared to venlafaxine. Method ：90 cases were divided into two groups randomly, treated with dutoxetine and venlafaxine respectively for 8 weeks. The Hamilton anxiety scale （HAMA）, clinical global impression scale （CGI-SI） and treatment emergent symptom scale （TESS） were used to assess the therapeutic effect and side effect respectively. Results：The effective power of dutoxetine group and venlafaxine group are 84.44% and 82.22% respectively. There was no significant difference between two groups in improvement rate and side effect （P 〉 0.05）. Conclusion： Dutoxetine is as effective as venlafaxine for the treatment of GAD with fewer side effect and worth clinical application.
出处
《临床精神医学杂志》
2010年第1期42-43,共2页
Journal of Clinical Psychiatry
关键词
度洛西汀
文拉法辛
广泛性焦虑症
dutoxetine
venlafaxine
generalized anxiety disorder
