摘要
目的;比较不同剂量的瑞芬太尼复合异丙酚麻醉诱导对气管插管时的血液动力学影响。方法:ASAⅠ-Ⅱ级择期全麻手术病人60例按瑞芬大尼诱导时的不同剂量随机分为3组。诱导:瑞芬太尼(R1组1μg·mg^(-1)、R2组2μg·mg^(-1)、R3组3μg·mg^(-1),90s内推注完。),异丙酚以5 mg/5s静推直至意识消失,维库溴胺0.1mg·kg^(-1),顺序静脉注射,待肌松满意后行气管插管。分别记录病人入室、诱导后、插管前即刻、插管后1、3、5min的血压,心率及异丙酚用量。并观察诱导时有无呛咳,肌僵等并发症。结果:3组一般情况差异无显著性,各组插管后的血压均高于插管前,HR无显著变化。麻醉诱导时R2,R3组异丙酚的用量较R1组少·R1组插管反应的发生率较高,R3组诱导时呛咳,肌僵的发生率较高,且循环抑制较强。结论:瑞芬太尼复合异丙酚诱导呈现协同作用,以瑞芬太尼2μg·mg^(-1)为较为合适剂量。
：Objective： To compare the bemodynamic changes aitcr anesthesia induction with different doses of remifentanil in combi- nation of propofol. Methods;Sixty ASA Ⅰ - Ⅱ patients undergoing electived surgery under general anesthesia were enrolled in this study. The patients were randomized to receive remifentanil 1,2,3μg .mg-1 except for difficulty in tracheal intubation Propofol were injected with 5mg . 5second until loss of conscious. Tracheal was then intubated following intravenous weeuronium 0. ling . kg-1. We measured artiat blood pressure and HR be_fore anesthesia,induction after induction lmin, 3min, 5min,after intubation and induction complications like cough muscle rigid were observed. Resutt： Patients basic condition were similar in three groups. BP after intubaion of were signigicantly higher than those before intubaion, there were no signigicantly change in either group. HR remained stable after induction of anesthesia. The incidence of intubaion reponse was higher in group R1, complications like cough,muscle rigid circulation depression during induction were higher in group R3 ,compared with group Rland group R2. Con- clusion ： Induction with different doses of remifentanil in combination of propofol provide positive interaction and the Remifentanil 2μg.mg-1 is a suitable dose which can effectively attenuate the intubation response.
出处
《内蒙古中医药》
2010年第1期15-17,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
瑞芬太尼
异丙酚
气管插管
Remifentanil
Propofol
Tracheal intubation
