摘要
目的研究松针不同部位提取物对去卵巢大鼠肝脏脂质的影响。方法Wistar雌性大鼠50只,分成正常组、模型组、松针正丁醇部位组、松针水部位组、松针多糖部位组,每组10只。术后1周开始给药,每周测量1次体质量,给药14周后处死动物,取肝脏并且测定肝脏甘油三酯,胆固醇及血清中的甘油三酯,胆固醇。结果松针多糖能显著抑制去卵巢大鼠肝脏和血清甘油三酯的升高,但对肝脏总胆固醇变化无影响。结论松针多糖对去卵巢大鼠肝脏甘油三酯有降低作用,并且对去卵巢大鼠肝脏脂肪堆积有改善作用。
Objective To study the effect of pine needle＇s different part extracts on liver lipids in ovariectomized rats. Methods 50 female Wistar rats were randomly divided into 5 groups： normal group, model group, n-butanol part group, water part group and polysaccharides part group with 10 rats in each group. All rats were ovariectomized except for the normal group. One week after operation, the rats were treated with different medicines. Fourteen weeks after treatment, the rats were killed; the weight, the liver exponent and the levels of TG and TC in serum and liver were measured. Results Compared with model group, the polysac-charides part could significantly decrease the level of triglycerde in both serum and liver of ovariectomied rats, but had no effect on the content of total cholesterol in liver. Conclusion The polysaccharides part of pine needle extract can decrease the level of triglycerde and the fat accumulation in liver of ovariectomied rats.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第2期368-370,共3页
Lishizhen Medicine and Materia Medica Research
基金
河南省高校新世纪优秀人才支持计划(No.2006HANCEF08)
关键词
松针提取物
去卵巢大鼠
肝脏脂质
Pine needles extract
Ovariectormized rats
Liver lipids
