期刊文献+

老年非小细胞肺癌的靶向治疗

Targeted therapy for elderly patients with non-small cell lung cancer
原文传递
导出
摘要 随着肿瘤细胞生物学的进展,已研制出许多针对特异性分子靶向的治疗药物,而且在晚期非小细胞肺癌患者的一线和二线治疗中均已显示出较好的疗效,由于老年患者有着生理学、药理学等各方面的特点,对化疗耐受性差,而针对此类患者的分子靶向治疗具有重要临床价值。 With the development of tumor cell biology, many targeted therapy drugs that aim specifically to inhibit tumor growth have been developed. Application of targeted drugs as first-line and second-line therapy in patients with advanced non-small cell lung cancer (NSCLC)have acquired exciting curative effect. Molecular targeted therapy for old patients have important clinical values,because old patients have weak toleration to chemotherapy as a result of physical and pharmacological features.
出处 《国际肿瘤学杂志》 CAS 2009年第12期932-934,共3页 Journal of International Oncology
基金 浙江省医药卫生科学研究基金资助项目(2008A142)
关键词 老年人 非小细胞肺 靶向治疗 Aged Carcinoma,non-small-cell lung Targeted therapy
  • 相关文献

参考文献18

  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics 2006. CA Cancer J Clin, 2006, 56(2) :106-130.
  • 2Gridlli C, l.anger C, Maione P, et al. Lung cancer in the elderly. J Clin Oncol, 2007, 25(14) :1898-1907.
  • 3Chang GC, Tsai CM, Cllen KC, et al. Predictive factnrs nf gefitinib antitumor activity in East Asian advanced non-small ccll lung cancer patients.J Thorac Oncol, 2006, 1(6) :520-525.
  • 4Takashi N, Nobuyuki K, Masshi K, et al, Phase Ⅱ study of gefitinib as a first-line therapy in elderly patients with lung adenocarcinoma ( WJTOG0402 - DI). J Thorac Oncol, 2007, 2 (8s) : s730- s731.
  • 5Hntta K, Ueoka H, Kiura K, et al. Safety and efficacy of gefitinib treatment in elderly patients with non-small-cell lung eaneer: okayama lung cancer study group experience. Acta Oncol, 2005, 44 (7) :717- 722.
  • 6Stinchcombe TE, Buzkova P, Choksi J, et al. A phase Ⅰ/ Ⅱ trial of weekly docetaxel and gefitinib in elderly patients with stage Ⅲ B/Ⅳ non- small cell lung tauter. Lung Cancer, 2006, 52 (3) :305-311.
  • 7Scagliotti G, Rossi A, Novello S, el al. Gefitinib( ZD 1839) combined with gemcitabine or vinorelbine as single-agent in ehterly patients with advanced non-small cell lung cancer(NSCLC). J Clin Oncol, 2004, 23(14S) :636s.
  • 8Jaekman DM, Yeap BY, Lindeman Nl, et al. Phase Ⅱ clinical trial of chemotherapy-naive patients > 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J Clin Oncol, 2007, 25 (7) : 760-766.
  • 9Lynch T Jr, Kim E. Optimizing chemotherapy and largeted agent combinations in NSCLC. Lung Cancer, 2005, 50 (Suppl2) :S25-S32.
  • 10Clark GM, Cameron T, Das Gupta A. Clinical benefit of erlotinib in male smokers with squamous-cell NSCLC. J Clin Oncol, 2006, 24 (Soppl 18) :7166.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部