摘要
在胆道领域，基本的损伤修复研究显著落后于皮肤及胃肠道领域。其中部分原因是因为胆道的损伤修复的研究相对困难。但因其临床意义重大，人们对胆管上皮的病理生理学越来越感兴趣，胆管上皮的培育成功彻底扭转了这种趋势。在肝外胆管，损伤修复的不足、瘢痕、狭窄可压迫组织。在肝内小胆管，受损的胆管上皮细胞以及过度反应导致肝脏疾病，慢性感染和持续的损伤修复常可引起肝硬化及肝癌。
The wound healing research in the biliary tree lag significantly behind similar studies on the skin and gastrointestinal tract. This is at least partly attributable to the difficulty to study on the biliary tract . But clinical relevance, more interest in biliary epithelial cell （BEC） pathophysiology, and widespread availability of BEC cultures are factors reversing this trend. In the extra-hepatic biliarv tree,ineffectual wound healing, scarring and stricture development are pressing issues. In the smallest intra-hepatic bile ducts either impaired BEC proliferation or an exuberant response can contribute to liver disease. Chronic inflammation and persistent wound healing reactions in large and small bile ducts often lead to hepatic cirrhosis and liver cancer.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2010年第1期73-76,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
胆管
损伤修复
肝脏疾病
Bile duct
Wound healing
Liver diseases
