摘要
目的探讨雌孕激素水平及免疫功能变化与妊娠肝内胆汁淤积症（ＩＣＰ）的关系。方法采用放射免疫法、单向免疫扩散法、碱性磷酸酶及抗碱性磷酸酶法（ＡＰＡＡＰ）检测ＩＣＰ孕妇５０例（ＩＣＰ组）及正常妊娠妇女５０例（对照组）雌孕激素水平的变化、体液免疫和细胞免疫功能的水平。结果ＩＣＰ组雌激素水平（２５．８９±６．８５μｇ／Ｌ）较对照组（１６．９２±４．９８μｇ／Ｌ）明显升高，（Ｐ＜０．０１），孕激素水平差异无显著性（Ｐ＞０．０５）；ＩＣＰ组细胞毒性抑制性Ｔ细胞（ＣＤ８＋）水平（１９．０６±１．９３％）较对照组（２６．４３±２．８９％）降低（Ｐ＜０．０５），辅助性诱导性Ｔ细胞（ＣＤ４＋）与ＣＤ８＋比值（２．２３±０．３８）较对照组（１．７３±０．２３）升高（Ｐ＜０．０５）；雌激素水平与ＣＤ８＋呈负相关，与ＣＤ４＋／ＣＤ８＋比值呈正相关。结论ＩＣＰ患者雌激素水平增高，雌激素通过ＣＤ８＋上的雌激素受体而发挥作用，导致免疫功能的改变。
Objective To explore the effects of estrogen, progesterone and the function of immune system on intrahepatic cholestasis of pregnancy (ICP). Methods Fifty women with ICP and fifty normal pregnant women were enrolled in the study. The levels of their serum estradiol (E 2) and progesterone (P) were measured and cellular immunity and humoral immunity were determined. Radioimmunoassay was used to detect the levels of E 2 and P, and APAAP was used to detect cellular immunity. Results (1)The level of estrodiol was significantly increased in ICP group than those of normal control group (25.89±6.85 μg/L, 16.92±4.98 μg/L, P <0.01). (2)The level of CD 8 + was decreased (19.06±1.93%, 26.43±2.89%)and the ratio of CD 4 +/ CD 8 + was increased significantly in ICP group than those of control group (2.23 ±0.38, 1.73 ±0.23, P <0.05). (3)There were negative correlation between E 2 and CD 8 +, and positive correlation between E 2 and the ratio of CD 4 +/ CD 8 +. Conclusion These results suggest that the high level of E 2 of ICP patients may result in functional disorder of immune system by the means of estrogen receptor on CD 8 +. This may be a factor of ICP development.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1998年第12期724-726,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
胆汁郁积
妊娠合并症
雌激素类
孕酮
Cholestasis,intrahepatic Pregnancy Estrogens Progesterone Immunity, cellular
