摘要
目的评估胰岛素样生长因子Ⅰ（ＩＧＦⅠ）在胎儿、胎盘生长发育中的作用。方法用放射免疫分析法（ＲＩＡ）测定大于胎龄儿（ＬＧＡ）组３０例，适于胎龄儿（ＡＧＡ）组３６例及小于胎龄儿（ＳＧＡ）组３６例的脐血清ＩＧＦⅠ的水平。用线性相关分析法分析各组变量之间的相关关系。结果３组胎儿脐血清ＩＧＦⅠ与胎龄、胎儿体重、胎盘重量均呈显著正相关（ｒ＝０．３２，Ｐ＜０．００１；ｒ＝０．６８，Ｐ＜０．００１；ｒ＝０．７５，Ｐ＜０．０１），其中与胎盘重量呈高度正相关。脐血清ＩＧＦⅠ水平，ＡＧＡ组为１４４５９±４６．７３μｇ／Ｌ；ＳＧＡ组为９０．８０μｇ／Ｌ（ｔ＝４．７，Ｐ＜０．００１），ＬＧＡ组为２０９１７μｇ／Ｌ（ｔ＝７．９７，Ｐ＜０．００１）。结论ＩＧＦⅠ是胎儿、胎盘生长发育的重要调节因子，对巨大儿、小于胎龄儿的形成有重要作用。
Objective To evaluate the role of insulin like growth factor Ⅰ(IGF Ⅰ) in fetal growth and placental growth. Methods Cord blood IGF Ⅰ was determined by radioimmunoassay (RIA) after serum samples were extracted with acid ethanol. Linear correlation between variables was tested by calculating pearson's correlation coefficient. student's test was used to compare mean values between groups. Results In 102 tested samples, the concentration of cord blood serum IGF Ⅰ was correlated with the gestational age, the birth weight of neonates and placental weight ( r=0.32, P<0.001, r=0.68, P<0.001, r=0.75, P<0.001). The mean serum level of IGF Ⅰ in the small for gestational age (SGA) neonates was significantly lower than that in average for gestational age (AGA) ( t=4.77, P<0.001), But the serum concentration of IGF Ⅰ in the Large for gestational aga (LGA) neonates was significantly higher than that of AGA neonates ( t=7.97, P<0.001). Conclusion Those results suggested that IGF Ⅰ is an important regulator for fetal and placental growth and development. It has the key role for macrosomia and IUGR forming.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1998年第12期720-721,共2页
Chinese Journal of Obstetrics and Gynecology
