摘要
目的：了解幼儿龋病活跃性与唾液部分生化指标的关系，为筛选龋病活跃性幼儿提供理论依据。方法：对１１０名３～４岁幼儿非刺激性全唾液的ｐＨ值、ＨＣＯ－３、溶菌酶（ＬＺＭ）、乳酸脱氢酶（ＬＤＨ）和碱性磷酸酶（ＡＫＰ）进行测定。ｐＨ值用ＰＨＳ－３Ｃ型酸度计测定；ＬＺＭ用微量快速比色法测定；ＨＣＯ－３用改良滴定法测定；ＬＤＨ用比色法测定；ＡＫＰ用磷酸苯二钠法测定。结果：无龋幼儿（龋补齿数：ｄｆｔ＝０，４９名）唾液ｐＨ值及ＬＺＭ活性显著高于多龋幼儿（ｄｆｔ≥５，４３名）（Ｐ＜０．０１），ＨＣＯ－３、ＬＤＨ、ＡＫＰ两组间无显著差异（Ｐ＞０．０５），并且龋病幼儿（ｄｆｔ为１～１８，６１名）的ＬＺＭ活性与ｄｆｔ呈显著负相关关系（ｒ＝－０．２５１，Ｐ＜０．０５）。结论：幼儿龋病活跃性与唾液ＬＺＭ活性有关。
Objective: To explore the relationship between salivary biochemical indices and caries activity in children and provide scientific basis for precautions against caries in children. Methods: pH, HCO - 3 and activitifes of lysozyme(LZM), lactate dehydrogenase(LDH), alkaline phosphatase(AKP) in saliva wre measured in 110 3￣4 years old children, 49 in caries free(CF) group (dft=0), 61 in caries group (dft=1￣18) including 43 in caries susceptible (CS) group (dft≥5). Results: Both the activity of LZM and the level of pH in CF group were significantly higher than those in CS group (P<0.01), and there was a significant negative correlation between the activity of LZM and the dft score in caries group (r=-0.251, P<0.05). However, the activities of LDH, AKP and the level of HCO - 3 were not found to have significant difference between CF group and CS group (P>0.05). Conclusion: The activity of LZM in saliva is related to caries activity in children.
关键词
龋病活跃性
唾液
生化指标
龋齿
儿童
caries activity
salivary biochemical indices
children
