摘要
将24例长期血透（HD）患者随机分为3组，每组8例，分别采用钢仿膜、血体膜、聚砜膜透析器，以白细胞介素1β（IL－1β）、肿瘤坏死因子α（TNFα）作为膜生物相容性指标。用酶联免疫法测定3组患者血迹前、透析器首次使用及第4次使用后IL－1β、TNFα的水平。发现IL－1β、TNFα的水平依次为聚识膜＜血信膜＜铜仿膜，复用透析恐后IL-1β、TNFα水平与各组进前比无显著性差异（P＞0．05）。认为合成膜的生物相容性优于纤维素膜，复用透析器可改善膜的生物相容性。
in order to offer theoretie evidencefor clinic to select dialyzers reasonably, 24 chronichemodialysis patients were dialyzed with cuprophone (CU) hemophone (Hemo) and polysulphone(PS) dialyzer respectively. The interleukin-1β (IL1β) and tumor necrosis factor Q (TNFα) as markersof membrane biocompatibility were observed by enzyme immunoassay after using different dialysismembranes. IL-1β and TNFα were measured preand post hemodialysis when different dialyzers werefirst and fourthly used. The results demonstratedthat the levies of IL-1β and TNFα were PS<HemO<CU in turn. The levels of IL-1β and TNFα compared with prehemodialysis have no statistically significant difference. The conclusion was that the biocompatility of the synthetic membrane was betterthan that of cellulosic membrane. The membranebiocompatibility can be improved when the dialeris reused.
出处
《西安医科大学学报》
CSCD
1998年第4期604-606,共3页
Journal of Xi'an Medical University(Chinese)
