摘要
以成人桥本氏病60例为对照，分析了60例儿童桥本氏病。显示：①阳性的自身免疫甲状腺病家族史较成人组多见（P＝0.0126）；②甲状腺峡部大为主者多于成人组（X2=49，P＜0.05）；甲状腺质地硬或韧如橡皮者显著少于成人组（X2=12．48，P＜0．001），伴结节者显著少于成人组（X2=8．2，P＜0.01）；③甲状腺球蛋白抗体（TGAb）和微粒体抗体（TMAb）阴性者显著多于成人组（X2=5．1和X3=5．81，P均＜0．05）；④淋巴细胞型显著多于成人组（X2=7.01，P＜0．01），而嗜酸细胞型明显少于成人组（X3=3．89，P＜0．05）；⑤甲状腺肿大程度、生化和碘代谢，两组相比差异无显著性（P＞0．05）。
in order to study the clinical and laboratorycharacters of the child Hoshimoto's disease,we investigated60 child cases. Comparing with the adult Hoshimoto's disease cases (n = 60) which are chosen randomly and diagnosied by thyroid cytological and/or histological evidence,child Hoshimoto's disease (n = 60,age<14 years) had thefollowing characters= (1 ) More cases with positive familyhistory could be found in child group than in adult group(P = 0. 0126) ; (2) Enlargement of thyroid isthamus appeared more frequently in child group than in adult group(ac = 4. 9, P < 0. 05 ), but the number of patients havingfirm of tough-rubber-like thyroid gland in adult group issignificant more than that in child (X2= 12. 48, P <0. 001)and in the adult group more patients could be found thyroidnodules (σ2 = 8. 2, P <0. 01 ) ; (3)The number of patientswith negative TGAb and TMAb in child group was significant more than that in adult group (X2= 5. 1, P <0. 05 andac = 5. 81, P < 0. 05 ) ; (4)The cytology and/or histologystudy showed that pathological type of lymphocyte in childpatients was more than that in adult group (X2=7. 01, p <0. 05), while the type of eosinophil was less than that of theadult group (X2= 3. 83, P <0. 05) ; (5)No significant difference of biochemistry, metabolism of iodine and the size ofthyroid gotter,could be found between the child group andthe adult group (P >0. 05).
出处
《西安医科大学学报》
CSCD
1998年第4期579-582,共4页
Journal of Xi'an Medical University(Chinese)
关键词
桥本病
儿童
抗体
实验室诊断
thyroid gland
Hoshimoto's disease
child
autoantibody
