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超声对恩度联合新辅助化疗治疗乳腺癌的疗效观察 被引量:9

Ultrasonic evaluation of therapeutic effect of Endostar combined with neoadjuvant chemotherapy for breast cancer
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摘要 目的:探讨彩色多普勒超声检查在恩度联合新辅助化疗治疗乳腺癌疗效评估中的价值。方法:分别于治疗前后应用彩色多普勒超声对38例乳腺癌的40个乳腺病灶及腋窝淋巴结进行观察及分析。结果:40个病灶中34个治疗有效,病灶内血流信号分级降低或血流消失;Vm ax值明显降低(P<0.05);化疗前发现异常淋巴结共32个,治疗后有28个缩小或消失,30个血流信号明显减少。超声评估原发肿瘤缓解的总有效率为85%(34/40)。结论:超声检查可为恩度联合新辅助化疗治疗乳腺癌提供简便、安全的疗效观察手段。 Objective:To investigate the value of ultrasonic assessment of therapeutic effect of Endostar combined with neoadjuvant chemotherapy for breast cancer.Methods: Thirty-eight patients with breast cancer(40 breast lesions and 32 abnormal axillary lymph nodes) were examined before and after the combined treatment.Results:After combined treatment,the color Doppler signals of 34 breast lesions decreased or vanished,and the value of Vmax significantly reduced.Of the 32 abnormal axillary lymph nodes,28 reduced in volume or vanished after chemotherapy,and the color Doppler signals of 30 lymph nodes significantly deceased.The total effective rate of ultrasonic evaluation was 85%.Conclusion:After the combined therapy,the color Doppler signal of breast tumor and axillary lymph nodes was decreased significantly.Ultrasonography is a convenient and safe tool for assessing the therapeutic effect of the Endostar combined with neoadjuvant chemotherapy for breast cancer.
出处 《西北国防医学杂志》 CAS 2010年第1期49-50,共2页 Medical Journal of National Defending Forces in Northwest China
关键词 超声波诊断 恩度 新辅助化疗 乳腺癌 Ultrasonic diagnosis Endostar Neoadjuvant chemotherapy Breast cancer
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  • 1王金万,孙燕,刘永煜,于起涛,张沂平,李凯,朱允中,周清华,侯梅,管忠震,李维廉,庄武,王东林,梁后杰,秦凤展,卢辉山,刘晓晴,孙红,张燕军,王杰军,罗素霞,杨瑞合,涂远荣,王秀问,宋恕平,周静敏,游丽芬,王竞,姚晨.重组人血管内皮抑素联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究[J].中国肺癌杂志,2005,8(4):283-290. 被引量:630
  • 2竺东长,姚榛祥,吴凯南,涂天喜,吴诚义,钟晓明,陈受田.乳腺癌区域淋巴结B超扫描诊断的探讨[J].重庆医科大学学报,1996,21(1):39-42. 被引量:1
  • 3HAJITOU A,GRIGNET C,DEVY L,et al.The antitumoral effect of endostatin and angiostatin is associated with a downreguration of vascular endothelial growth factor expression in tumor cells[J].FASEB J,2002,16(13):1 802-1 804.
  • 4REN B,HOTI N,RABASSEDA X,et al.The antiangiogenic and therapeutic implications of endostatin[J].Methods Find Exp Clin Pharmacol,2003,25(3):215-224.
  • 5FOLKMAN J.Endogenous angiogenesis inhibitors[J].APMIS,2004,112(7-8):496-507.
  • 6KANG H Y,SHIM D,KANG S S,et al.Protein kinase B inhibits endostatininduced apoptosis in HUVECs[J].J Biochem Mol Biol,2006,39(1):97-104.
  • 7BERTOLINI F,FUSETTI L,MANCUSO P,et al.Endostatin,an antiangiogenic drug,induced tumor stabilization after chemotherapy or anticd20 therapy in a NOD/SCID mouse model of human high grade non Hodgkin lymphoma[J].Blood,2000,96(1):282-287.
  • 8HANAI J,DHANABAL M,KARUMANCHI S A,et al.Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1[J].J Biol Chem,2002,277(19):16 464-16 469.
  • 9KIM Y M,HWANG S,KIM Y M,et al.Endostatin blocks vascular endothelial growth factormediated signaling via direct interaction with KDR/F1K1[J].J Bio Chem,2002,277(31):27 872-27 879.
  • 10URBICH C,REISSNER A,CHAVAKIS E,et al.Dephosphorylation of endothelial nitric oxide synthase contributes to the antiangiogenic effects of endostatin[J].FASEB J,2002,16(7):706-708.

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