摘要
目的探讨胸腺肿瘤临床病理学特点。方法分析31例胸腺肿瘤的临床病理学特点和随访资料。结果31例胸腺肿瘤中,A型2例(6.45%),AB型7例(22.58%),B1型3例(9.68%),B2型12例(38.71%),B3型5例(16.13%),胸腺癌2例(6.45%)。Masaoka临床分期:Ⅰ期11例(35.48%),Ⅱ期9例(29.03%),Ⅲ期6例(19.36%),Ⅳa期5例(16.13%)。组织学分型与临床分期具有显著的相关性。免疫组化结果p53阳性18例(58.06%),Ki-67阳性15例(48.39%)。结论WHO组织学分型能反映胸腺瘤各亚型的生物学行为,胸腺肿瘤的Masaoka分期是影响胸腺瘤患者生存的最重要的独立预后参数,WHO组织学分型和肿瘤是否切除彻底是影响胸腺瘤患者预后的重要决定因素。
Objective To investigate the clinicopathological characteristics of thymoma.Methods The clinicopathologic features and following-up date of 31 patients with thymoma were analysized.Results Of 31 cases,2 cases（6.45%）were type A,7 cases（22.58%）type AB,3 cases（9.68%）type B1,12 cases（38.71%）type B2,5 cases（16.13%）type B3.Thymic carcinoma was diagnosed in 2 cases（6.45%）.According to Masaoka clinical staging,11 cases（35.48%）were in stageⅠ,9 cases（29.03%）in stag Ⅱ,6 cases（19.36%）in stage Ⅲ,5 cases（16.13%）in stage Ⅳa.Histological classification was significantily correlatied to clinical stages.The positive rates of p53 and Ki-67 were 58.06%（18/31）and 48.39%（15/31）,respectively.Conclusion WHO histological classification in thymoma can reflect the biological behaviors of the tumor.Masaoka clinical stage is the most important independant factor for predicting the prognosis of thymoma patients.The histological classification and completeness of resection of the tumor are the main factors to affect prognosis.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第1期24-26,共3页
Jiangsu Medical Journal
