摘要
目的探讨PTEN基因、基质金属蛋白酶（MMP）-2和MMP-9在胸腺瘤中的表达及其与胸腺瘤临床病理特征的关系。方法应用免疫组织化学sP方法，检测45例胸腺瘤和16例非瘤胸腺（对照组）组织中PTEN、MMP-2和MMP-9的表达。结果PTEN、MMP-2和MMP-9在胸腺瘤组织中的阳性表达率分别为53．5％、48．9％和62．2％，在对照组中的阳性表达率分别为93．8％、6．3％和25．0％，差异均有统计学意义（P〈0．05）。PTEN和MMP-2的表达与胸腺瘤的恶性程度（世界卫生组织分型）有关（P〈0．05），与胸腺瘤的侵袭性（Masaoka分期）有关（P〈0．01）。MMP-9的表达与胸腺瘤的恶性程度和侵袭性无关（P〉0．05）。结论PTEN、MMP-2和MMP-9与胸腺瘤的发生、发展可能有关，且PTEN和MMP-2与胸腺瘤的恶性程度和侵袭性相关。
Objective To evaluate the expression of PTEN, MMP-2 and MMP-9 in thymomas and their correlation with clinical significance. Methods Immunohistochemical S-P assay was used to detect the expression of PTEN, MMP-2 and MMP-9 in 45 thymomas and 16 non-neoplastic thymuses. Results The positive rate of PTEN, MMP-2 and MMP-9 expression in 45 thymomas were 53.5% , 48.9% and 62.2%, respectively. There were significant differences between non-neoplastic thymus and thymomas （ P 〈 0. 05 ）. The expression of PTEN, MMP-2 correlated with histological type （P 〈 0.05 ） and different clinical stage of the thymoma （P 〈0.01 ）. The expression of MMP-9 was not correlated with histological type and different clinical stages of thymoma （ P 〉 0.05 ）. Conclusion PTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma. The expression of PTEN and MMP-2 correlates with the malignance and the aggression of thymoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2010年第1期37-39,共3页
Chinese Journal of Oncology
