摘要
骨髓间充质干细胞（MSC）是骨髓组织中具有多向分化潜能的一类非造血性干细胞，并可通过多种机制参与骨髓造血微环境调控及免疫功能调节，在组织工程、基因治疗、干细胞移植后移植物抗宿主病（GVHD）中应用前景广泛，是医学研究的热点。现就MSC在造血干细胞移植（HSCT）、再生障碍性贫血（CA）、多发性骨髓瘤（MM）中的研究现况及其潜在应用价值作一简要综述。
Bone marrow mesenchymal stem cells （MSC） are the non-hematopoietic cellular component in the bone marrow that have multiple differentiation potency. MSC play a key role in the regulation of bone marrow hematopoietic niche and modulation of immune function through various mechanisms. They are currently recognized as a promising cell source in tissue engineering, a vehicle in gene therapy and a powerful tool in the management of graft-versus-host disease after allogeneic stem cell transplantation. In this review some momentous aspects regarding the current status and potential clinical applications of MSC in hematopoietic stem cell transplantation, aplastic anemia and multiple myeloma were summarized.
出处
《白血病．淋巴瘤》
CAS
2010年第1期58-61,共4页
Journal of Leukemia & Lymphoma
基金
基金项目：上海市自然科学基金（08ZRl414800）
关键词
间质干细胞
血液病
Mesenchymal stem cells
Hematologic diseases
