摘要
目的:通过观察原发性高血压患者循环内皮祖细胞(EPCs)与颈动脉内膜中层厚度(IMT)及炎性介质的相关性,进一步探讨其在此类患者发病机制中的作用。方法:测定50例初诊原发性高血压患者和50例健康者的EPCs数量、超敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和IMT等指标。结果:高血压患者的颈动脉IMT、Hs-CRP、IL-6、TNF-α、收缩压和脉压均显著高于健康者(P<0.05);EPCs数量显著低于健康者(P<0.05)。EPCs数量与颈动脉IMT(r=0.577)、Hs-CRP(r=0.483)、IL-6(r=0.442)和脉压(r=0.390)呈显著负相关。结论:高血压的发生发展是内皮系统、血管重构和炎性反应等多因素综合作用的结果。
Objective .. To investigate the correlation between circulating endothelial progenitor cells （EPCs） and carotid intima-media thickness （IMT）,inflammatory mediators and evaluate mechanism of essential hypertension. Methods：The amount of EPCs, hyper sensitive C-reactive protein （Hs-CRP）, interleukin-6 （IL- 6）,tumor necrosis factor-α （TNF-α） and IMT were measured in 50 newly diagnosed hypertensives and 50 healthy persons. Results ： Compared with healthy persons, IMT, Hs-CRP, IL-6, TNF-α, systolic pressure and pulse pressure were significantly increased （P〈0. 05） ,while the amount of EPCs was reduced in patients with essential hypertension （P〈0. 05）; the amount of EPCs was negatively correlated with IMT （r= 0. 577）,Hs- CRP （r=0. 483）,IL-6 （r=0. 442） and pulse pressure （r=0. 390）. Conclusion ：The occurance of hypertension is decided by interrelation of endothelial system, vascular remodeling and inflammation.
出处
《陕西医学杂志》
CAS
2010年第2期207-209,共3页
Shaanxi Medical Journal
关键词
高血压
内皮祖细胞
颈动脉内膜中层厚度
C反应蛋白
白介素-6
Hypertension Endothelial progenitor cells Carotid intima-media thickness C-reactive protein Interleukin-6
