摘要
目的:探讨胆固醇酯转运蛋白(CETP)TaqIB基因多态性与视网膜中央静脉阻塞的关系。方法:采用多聚酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)技术检测60例经视网膜荧光造影诊断的视网膜中央静脉阻塞患者和120例对照者的CETP基因多态性。结果:视网膜中央静脉阻塞组B1/B1基因型频率(33.3%)明显高于对照组(12.5%)(P<0.05),B1等位基因频率(51.8%)也明显高于对照组(31.8%)(P<0.05)。结论:CETP基因和视网膜中央静脉阻塞的发病有关。
Objective：To investigate the relationship of the cholesteryl ester transfer protein（CETP） TaqIB polymorphism with central retinal vein occlusion（CRVO）. Methods： The CETP TaqIB gene genotypes were determined in 60 CRVO patients who were diagnosed by retinal fluorescence angiography and 120 subjects without CRVO by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Results： CRVO group B1/B1 genotype frequency （33. 3%） was significantly higher than that （12. 5%）in the control group （P〈0. 05）, B1 allele frequency （51.8%） also was significantly higher than that （31.8%） in the control group （P〈0. 05）. Conclusion： Genetic variations in CETP gene could be involved in the risk of CRVO.
出处
《陕西医学杂志》
CAS
2010年第2期165-166,共2页
Shaanxi Medical Journal
