摘要
目的:观察参芪扶正注射液辅助化疗治疗结直肠腺癌的疗效并探讨其作用机制。方法:选取结直肠腺癌患者38例并随机分为2组,试验组20例,采用参芪扶正注射液联合FOLFOX方案化疗;对照组18例,采用单纯FOLFOX方案化疗。检测2组患者治疗前后外周血中Treg细胞、白细胞介素-12(IL-12)、干扰素-γ(IFN-γ)的含量变化。同时,根据世界卫生组织抗癌药物急性及亚急性毒性反应分度标准进行分级统计。结果:结直肠腺癌患者Treg细胞含量较健康体检者明显升高。2组化疗后Treg细胞含量均降低;试验组IFN-γ、IL-12含量升高而对照组出现同步降低;试验组化疗毒副作用较对照组明显减轻。结论:参芪扶正注射液辅助化疗,不仅可以调节机体免疫系统提高化疗效果,而且还可以减轻化疗药物的毒副作用。参芪扶正注射液联合化疗治疗结直肠腺癌是一种较实用的方法。
OBJECTIVE： To probe into the efficacy and mechanism of Shenqifuzheng injection combined with chemotherapy in the treatment of colorectal carcinoma. METHODS： 38 patients with colorectal carcinoma were randomly received Shenqifuzheng injection comtined with FOLFOX chemotherapy （trial group, n=20） and FOLFOX chemotherapy alone （control group, n=18）. The content of Treg cells in peripheral blood of healthy subjects and patients with colorectal carcinoma was determined. The levels of Treg cells, IL-12 and IFN-γ were determined before and after chemotherapy. The toxic grade of the chemotherapy was measured according to the grade scale for acute and subacute. Toxic reaction of anticancer drugs was issued by WHO. RESULTS： As compared with healthy subjects, the content of Treg cells of peripheral blood in patients with colorectal carcinoma increased significantly. The content of Treg cells in two groups decreased after chemotherapy. The level of IL-12 and IFN-γ increased significantly in trial group while decreased in control group. As compared with control group, the toxic reaction of chemotherapy was weakened in trial group. CONCLUSION： Chemotherapy combined with Shenqifuz.heng injection not only can improve the efficacy of chemoherapy through regulating immune system but also reduce the toxic reaction of chemotherapy. In a word, Shenqifuzheng injection combined with chemotherapy is a practical way to cure colorectal carcinoma.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第4期357-359,共3页
China Pharmacy
基金
河北省卫生厅医疗卫生科研基金资助项目(08120)
关键词
参芪扶正注射液
结直肠腺癌
化疗
Shenqifuzheng injection
Colorectal carcinoma
Chemotherapy
