摘要
蛋白激酶Ｃ（ＰＫＣ）是至少包括１１种亚型在内的丝苏氨酸蛋白激酶家族，可分为传统型（ｃＰＫＣｓ）、新型（ｎＰＫＣｓ）、非典型（ａＰＫＣｓ）和ＰＫＣｕ四大类。各ＰＫＣ亚型在ＡＴＰ结合位点、磷脂酰基转移位点、假性底物位点、佛波酯结合位点的氨基酸序列既高度保守又有变异。ＰＫＣ在机体内分布和作用十分广泛，本文主要介绍了ＰＫＣ在肿瘤形成、侵润和转移及肿瘤耐药性产生，调节造血干祖细胞定向分化成熟。
Protein kinase C (PKC) is a serinethreonine kinase family consisting at least 11 related isoenzymes,and it can be divided into four distinct classes,conventional PKC (cPKCs),novel or new PKC (nPKCs),atypical PKC (aPKCs),and PKC u. All PKC members contain conserved and variant amino acid sequences in ATP binding sites,phosporyl transfer region,pseudosubstrate region,and phorbol ester binding sites.PKC isoenzymes exhibit distinct tissue distribution and play a critical role in cellular events. This review mainly summarized the PKC effects on tumorigenesis,tumor invasion and metastasis, tumor multidrug resistance, differentiation and development of hematopoietic progenitor cells,and hormonal production and secretion.
出处
《生理科学进展》
CAS
CSCD
北大核心
1998年第4期307-313,共7页
Progress in Physiological Sciences
关键词
蛋白激酶C
同工酶
分子结构
功能
Protein Kinase C
Isoenzyme
Molecular Structure
Function
