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肾素原及其受体的研究进展 被引量：4

Research progress in prorenin and prorenin receptor
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摘要 The renin-angiotension system (RAS) plays an important role in cardiovascular and renal physiology and diseases. Recent discoveries of prorenin and prorenin receptor add new contents to RAS. Renin and prorenin binding to the prorenin receptor not only target and facilitate angiotensin generation but also lead to activation of prorenin receptor signal transduction pathways,which is distinct from classical RAS signaling. In this paper,the construction,function and signal trasduction of prorenin,prorenin receptor and handle region peptide are reviewed. The renin - angiotension system （RAS） plays an important role in cardiovascular and renal physiology and diseases. Recent discoveries of prorenin and prorenin receptor add new contents to RAS. Renin and prorenin binding to the prorenin receptor not only target and facilitate angiotensin generation but also lead to activation of prorenin receptor signal transduction pathways, which is distinct from classical RAS signaling. In this paper, the construction, function and signal trasduction of prorenin, prorenin receptor and handle region peptide are reviewed.
作者 杨晓慧 卢新政
机构地区 南京医科大学第一附属医院心内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第2期405-408,共4页 Chinese Journal of Pathophysiology
关键词 肾原素 受体 肾原素 肾素-血管紧张素系统 信号转导 Prorenin Receptors, prorenin Renin - angiotensin system Signal transduction
分类号 R363 [医药卫生—病理学]
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参考文献27

  • 1Danser AH, Deinum J. Renin, prorenin and the putative (pro) reninreceptor [ J ]. Hypertension, 2005,46 ( 5 ) : 1069 - 1076.
  • 2Burckle C, Bader M. Prorenin and its ancient receptor [ J ]. Hypertension ,2006,48 (4) :549 - 551.
  • 3Ramser J, Abidi FE, Burckle CA,et al. A unique exonic splice enhancer mutation in a family with X - linked mental retardation and epilepsy points to a novel role of the re- nin receptor[J]. Hum Mol Genet, 2005, 14(8) :1019 - 1027.
  • 4Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin[ J]. J Clin Invest, 2002, 109(11) : 1417 -1427.
  • 5Nguyen G. Renin/prorenin receptors [ J ]. Kidney Int, 2006,69(9) : 1503 - 1506.
  • 6Saris JJ, Hoen PA, Garrelds IM, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II [ J ]. Hypertension, 2006,48 ( 4 ) : 564 - 571.
  • 7Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin- induced extracellular signal -regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle - region peptide [ J ]. Hypertension, 2008,51 ( 3 ) : 682 - 688.
  • 8Schefe JH, Menk M, Reinemund J, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein [ J ]. Circ Res, 2006,99 (12) :1355 - 1366.
  • 9Nurun NA, Uddin NM, Nakagawa T, et al. Role of "handle" region of prorenin prosegment in the nonproteolytic activation of prorenin by binding to membrane anchored (pro) reninreceptor [ J]. Front Biosci, 2007,12:4810 - 4817.
  • 10Batenburg WW, Krop M, Garrelds IM, et al. Prorenin is the endogenous agonist of the (pro) renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor [J].J Hypertens, 2007,25 ( 12 ) : 2441 - 2453.

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中国病理生理杂志
2010年 第2期

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