摘要
目的:评价静脉注射帕瑞昔布钠(parecoxi-sodium)用于急性轻型颅脑创伤术后镇痛的临床效果和安全性。方法:ASAⅠ-Ⅱ、年龄18～78岁、拟行急性轻型颅脑创伤手术患者60例,随机均分为2组(每组30例):帕瑞昔布钠组患者术后静脉注射帕瑞昔布钠40mg,对照组患者静脉注射等量生理盐水,观察术后24h盐酸曲马多的用量、术后镇痛病例数、术后的疼痛强度(VAS评分)、患者对镇痛的满意度、不良反应以及用药前后凝血功能的变化。结果:与对照组比较,帕瑞昔布钠组术后24h盐酸曲马多用量减少(P<0.05),术后镇痛病例数减少(P<0.05),术后VAS评分降低(P<0.05),术后24h患者对镇痛满意度提高(P<0.05),不良反应发生率降低(P<0.05),但术后2组凝血指标差异无显著性(P>0.05)。结论:急性轻型颅脑创伤术后静脉给予帕瑞昔布钠40mg可安全地减少术后曲马多用量,提高患者术后镇痛质量。
Objective To investigate the effectiveness and safety of administration of parecoxib sodium on the patients with acute slightly head injury for postoperative analgesia. Methods 60 patients with slightly head injury, ASAⅠ or Ⅱ, aged 18- 78 years, scheduled for acute neurosurgical operation were randomly divided into two groups （n= 30） ： pareeoxib sodium group received intravenous parecoxib -sodium 40 mg immediately after operation and control group received intravenous equivalence saline at the same time. The tramadol hydrochloride consumption at 24 h after operation, the number of unsatisfied demand and the number of successfully delivered doses were observed, and the intensity of pain was measured using VAS scores; the adverse effects, the patients＇ global evaluation of the postoperative analgesia and blood coagulation function before and after administration were recorded and compared between two groups. Results The tramadol hydrochloride consumption at 24 h after operation, the percentage of the patients who needed postoperative analgesia, and the VAS scores of the patients after operation in parecoxib-sodium group were significantly lower than those in control group （P〈0.05）. At the same time, the percentage of the patients in parecoxib-sodium group who considered the postoperative analgesia satisfied was higher than that in control group （P〈 0.05） . And the percentage of patients＇ adverse effects in parecoxib-sodium group was lower than that in control group （P〈0.05）. There was no significant difference in coagulation between parecoxib sodium group and control group （P〉0.05）. Conclusion Parecoxib 40 mg given in vein after neurosurgical operation can reduce the tramadol hydrochloride consumption and improve postoperative analgesia in patients with acute slightly head injury.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2010年第1期183-187,共5页
Journal of Jilin University：Medicine Edition
基金
天津市科委科技支撑计划项目资助课题(08ZCGYSF01600)
关键词
帕瑞昔布钠
颅脑损伤
盐酸曲马多
镇痛
parecoxib sodium
acute slightly head injury
tramadol hydrochloride
analgesia
blood clotting function
