摘要
目的:了解奎硫平与氟哌啶醇治疗精神分裂症的疗效及不良反应差异。方法:应用Meta分析对14篇研究奎硫平与氟哌啶醇治疗精神分裂症疗效及安全性的文献进行再分析,评价其合并总有效率、痊愈率、显效率及不良反应发生率。结果:①奎硫平与氟哌啶醇治疗精神分裂症总有效率合并分析总有效率之间差异无显著性(P=0.76);②奎硫平与氟哌啶醇治疗精神分裂症的痊愈率合并分析二者差异具有显著性(P=0.04);③与氟哌啶醇比较,奎硫平治疗精神分裂症的显效率更高(P=0.006);④奎硫平组的震颤、静坐不能、肌强直、口干和视物模糊等不良反应的发生率低于氟哌啶醇组(P<0.05),其余不良反应发生率二者之间比较差异均无显著性。结论:奎硫平与氟哌啶醇治疗精神分裂症总有效率相当,但奎硫平治疗精神分裂症的痊愈率及显效率明显好于氟哌啶醇;与氟哌啶醇比较,奎硫平可显著降低锥体外系反应的发生率。
Objective To assess the efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia and the differences in adverse effects of them. Methods Meta analysis on the 14 papers about efficacy and safety of quetiapJne and haloperidol in the treatment of schizophrenia was performed, and the total effective rate, cure ratative, obvious effective rate and adverse effects were evaluated. Results ① Haloperidol and quetiapine had similar total effective rate （P = 0.76）; ②there was significant difference of curative rate between haloperidol and quetiapine in treatment of schizophrenia （P=0. 04）; ③Compared with haloperidol, quetiapine had a higher obvious effective rate （P= 0.006）; ④the incidence rates of akathisia, myotonia, dry mouth etc in quetiapine group were lower than those in haloperidol group （P〈0.05）. Conclusion Quetiapine is better than haloperidol on the cure rate and obvious effective rate in the treatment of schizophrenia. Further, quetiapine has less extrapyramidal reactions.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2010年第1期169-174,共6页
Journal of Jilin University：Medicine Edition
基金
国家科技部"863"计划合作项目资助课题(2007AA03Z320)
