摘要
目的探讨冠心病危险因素对经皮冠状动脉介入（PCI）治疗预后的影响。方法回顾性分析2007年1月至2008年7月在兰州大学第一医院确诊为冠心病且行PCI治疗住院患者的冠心病危险因素。随访观察术后1年内发生不良心血管事件（MACE）的情况，分析其与冠心病危险因素的相关性。结果入选的446例患者，年龄32～80岁，平均（60．23±9．75）岁；男性84．97％（379／446），冠心病家族史者2．24％（10／446）；合并糖尿病者20．63％（92／446）；合并高血压病52．26％（242／446）；血脂异常42．15％（118／446）；体重超重62．33％（278／446）；吸烟者57．85％（258／446）。随访12个月内MACE发生率5．83％，经分析，女性、冠心病家族史、超重、高血压及吸烟患者在PCI术后1年内发生MACE与未发生MACE的患者人群差异均有统计学意义（X^2值分别为4．133、6．848、3．997、3．939、4．120，P均〈0．05）。Logistic回归分析结果示MACE与家族史、超重、性别相关（OR值分别为7．383、10．504、0．058，95％C1分别为1．639～33．246，1．231～89．598，0．014—0．236，P均〈0．05）。结论冠心病患者接受PCI治疗总体预后良好。PCI术后，冠心病危险因素（吸烟、高血压、超重等）仍需加以控制，以减少MACE的发生。
Objective To assess the influence of the risk factors of coronary heart disease （CHD） on the prognosis of percutaneous coronary interventions （PCI）. Methods The risk factors of CHD was retrospectively collected from 446 patients （ mean age （SD） ： 60.23 （9.75） yrs, 84.97 % male ） who were admitted to the First Affiliated Hospital of Lanzhou University from January,2007 to July, 2008. These patients were diagnosed as CHD and treated with PCI. Major adverse cardiac events （MACE） were followed up for 12 months after PCI ,and its association with the risk factors of CHD was investigated. Results Among all the patients,2.24% （10/446） had family history of CHD,20. 63% （92/446） was complicated with diabetes, 52. 26% （242/446） with hypertension,42. 15% （118/446） with dyslipidemia, 62. 33% （278/446） of the patients was overweight, and 57.85% （258/446） was smoker. Within 12 months of follow-up, MACE incidence rate were 5.83%. Univariate analysis showed the propor- tions of female, family history of CHD, overweight, hypertension and smoker were significantly different between the patients with MACE and those without MACE （~2 = 4. 133,6. 848,3. 997,3. 939,4. 120, respectively, P 〈 0.05 ）. Logistic regression analysis showed family history and overweight increased the risk of MACE （ OR = 7. 383 and 10.504,respectively,95% CI = 1. 639 - 33. 246 and 1. 231 - 59. 598, P 〈 0.05 ）, being male protected against MACE （ OR = 0. 058,95 % CI = 0.014 - 0. 236, P 〈 0.05 ）. Conclusions The prognosis of patients of CHD underwent PCI was good. After PCI, the risk factors of CHD such as smoking, hypertension , overweight, etc should be under control to decrease the occurrence of MACE.
出处
《中国综合临床》
2010年第2期144-147,共4页
Clinical Medicine of China
关键词
冠心病
危险因素
PCI治疗
预后
Coronary heart disease
Risk factor
PCI treatment
Prognosis
