摘要
目的观察蠲痛饮对子宫内膜异位症(EMS)大鼠血管内皮生长因子(VEGF)的影响,并探讨其治疗EMS的作用机理。方法采用自体子宫内膜移植法建立EMS大鼠模型,将60只大鼠随机分为蠲痛饮高、中、低剂量组及丹那唑组、模型组、空白组6组,药物组分别给予蠲痛饮高、中、低剂量(4.29、1.43、0.48g/100g)和丹那唑(2.15mg/100g)灌胃,模型组及空白组按照1mL/(100g·d)给予生理盐水灌胃,观察药物对EMS大鼠血清VEGF的影响。结果丹那唑组和不同剂量蠲痛饮对大鼠异位组织体积大小的影响,与模型组比较差异有统计学意义(P<0.05)。蠲痛饮高、中剂量降低EMS大鼠血清VEGF的水平,与模型组比较差异有统计学意义(P<0.05)。结论蠲痛饮可通过降低EMS大鼠血清VEGF水平,抑制异位组织的血管生成而抑制异位子宫内膜的发展,从而达到治疗EMS的目的。
Objective To research the effect of the influence of Juantongyin （JTY） on VEGF of endometriotic rats. Methods To observe the effect of high-dose, middle-dose, low-dose JTY and danazol on serum VEGF of endometriotic rats through setting up endometriosis model with rat self-endometria transplantation. Sixty rats were divided into 6 groups randomly： JTY high-dose group （4.29 g/100 g）, middle-dose group （1.43 g/100 g）, low-dose group （0.48 g/100 g）, and danazol group （2.15 rag/100 g）, model group and control group [i mL/100 （g · d） of saline]. Result There was a marked diversity among model group and other groups （P〈0.05] of the ectopic tissue volume. There was a marked diversity among high, middle-dose group and model group of serum VEGF levels of endometriotic rats. Conclusion JTY can inhibit the growth of endometrial transplants through reducing VEGF serum level of endometriotic rats.
出处
《中国中医药信息杂志》
CAS
CSCD
2010年第1期34-35,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
广西自然科学基金(桂科自0728186)
