摘要
目的探讨精氨酸改善梗阻性黄疸细胞免疫功能和增强抗感染措施．方法梗阻性黄疸患者６６例，分为非精氨酸（Ａ组）３７例（含急性梗阻性化脓性胆管炎，ＡＯＳＣ１４例）和精氨酸组（Ｂ组）２９例（含１例ＡＯＳＣ），研究两组手术前后细胞免疫变化和感染性并发症．结果不论手术前、还是手术后，Ｂ组ＣＤ＋３，ＣＤ＋４显著高于Ａ组（Ｐ＜００１，手术前ｔ值分别为７７５和５７２，手术后ｔ值分别为８８８和１０２８），ＳＩＬＩＲ显著低于Ｂ组（Ｐ＜００１，术前ｔ＝５１４，术后ｔ＝８７６）．Ｂ组ＡＯＳＣ术后感染性并发症显著低于Ａ组（Ｐ＜００１，χ２＝１３４２）．结论精氨酸能增强机体细胞免疫功能和降低术后感染．
AIM To improve cellular immune function and enhance measures against infection in patients with obstructive jaundice with arginine. METHODS Changes of cellular immunity and perioperative infection complications were studied in 37 patients (including 14 patients with AOSC) without arginine (group A) and 29 patients (including 11 patients with AOSC) with arginine treatment (group B). RESULTS Both pre or post operation, CD + 3 and CD + 4 were higher in group B than those of group A( P <0 01,pre operative t values were 7 75 and 5 72 and post operative t values were 8 88 and 10 28 respectively). But SIL 2R of group B was lower than that of group A ( P <0 01, pre operative t =5 14,post operative t =8 76). In AOSC, 7 days post operation body temperature and WBC were lower in group B than those of group A( P <0 01, t values were 7 32 and 4 23); and infectious complications of group A were obviously higher than those of group B ( P <0 01, χ 2=13 42). CONCLUSION Arginine can improve perioperation cellular immune function and reduce occurrence of post operative infections.
关键词
黄疸
免疫学
细胞免疫
精氨酸
jaundice/immunology
immunity, cellular
arginine
